IL28A

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IL28A

A gene on chromosome 19q13.13 that encodes interleukin-28A, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28A is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
References in periodicals archive ?
Human IL-28A, IL-28B, and IL-29, also known as interferon (IFN)-[lambda]2, -[lambda]3 and -[lambda]1, respectively, belonging to the type III IFNs.
This study aimed to investigate whether IL-28A plays a role in murine myocarditis induced by CVB3, and to explore its possible mechanism involved by determining the expressions of STAT1 and STAT2, Bcl-2, BAX, and Caspase-3 in CVB3-infected heart tissues.
Among them, 160 randomly selected mice were inoculated intraperitoneally with CVB3 (Nancy strain) at a dose of 105 plaque-forming units (pfu) in a volume of 100 [micro]L using phosphate buffered saline (PBS) as a vehicle, and divided evenly into 4 groups (n = 40), including infected but untreated group, low-dose, mild-dose and high-dose IL-28A treated groups.
TUNEL (terminal transferase-mediated 20-deoxyuridine 50-triphosphate-biotin nick end labeling) staining on paraffin-embedded sections was used to evaluate the effect of IL-28A on CVB3-induced apoptosis according to the instructions provided by the manufacturer.
IL-28A treatment protects mice from CVB3 infection-associated death
The product is a member of the Type III lambda interferon family, which includes IL-28A, IL-28B and IL-29, stated the partnership.