IL17C

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IL17C

A gene on chromosome 16q24 that encodes interleukin-17C, a cytokine which stimulates the release of tumour necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
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Ixekizumab does not bind to cytokines IL-17B, IL-17C, IL-17D, IL-17E or IL-17F and is administered via subcutaneous injection (under the skin).
We also performed a nested polymerase chain reaction assay for several genes of interest, including CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
Formalin-fixed paraffin tumor tissue was analyzed for the genes CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
IL-17A and IL-17C have been shown to have the ability to induce mRNA expression of inflammatory cytokines, including IL-1[beta], IL-6, and IL-23.
Our patient exhibited increased CTLA-4, IL-17A, IL-17C, and IL-17E expression in his mucosal melanoma (figure 4).