IL17C

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IL17C

A gene on chromosome 16q24 that encodes interleukin-17C, a cytokine which stimulates the release of tumour necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.
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Galapagos NV (GLPG) and MorphoSys (MPSYY) announced the presentation of more detailed results of the Phase 1 study with the investigational IL-17C antibody MOR106 in atopic dermatitis patients at the American Academy of Dermatology Annual Meeting 2018.
6) Levels of IL-17A, IL-17C, and IL-17F are increased in psoriatic skin, suggesting that these proteins may play roles in the pathogenesis of psoriasis.
We also performed a nested polymerase chain reaction assay for several genes of interest, including CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
Formalin-fixed paraffin tumor tissue was analyzed for the genes CTLA-4, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, IL-17F, PLZF, Foxp3, RORyt, CD27, and CD70.
IL-17A and IL-17C have been shown to have the ability to induce mRNA expression of inflammatory cytokines, including IL-1[beta], IL-6, and IL-23.
Our patient exhibited increased CTLA-4, IL-17A, IL-17C, and IL-17E expression in his mucosal melanoma (figure 4).
Table-1 The IL-Cytokine Family LIGAND RECEPTOR IL-17A IL-17RA IL-17B IL-17RB IL-17C IL-17RC IL-17D IL-17RD IL-17E IL-17RE IL-17F vIL-17
La localizacion cromosomica de los otros miembros de esta familia es como sigue: IL-17B en cr5q32, IL-17C en cr16q24, IL-17D en cr13q11 e IL-17E en cr14q11.
Estos autores encontraron tambien una produccion de IL-17C en este modelo, la cual no se veia afectada con el bloqueo de la actividad de la IL-23, como si le sucedia a IL-17A e IL-17F, sugiriendo una via alterna de produccion para esta citoquina.