IL-13


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Related to IL-13: IL-15, Il-4, Il-17

IL13

A gene on chromosome 5q31 that encodes interleukin-13, an immunoregulatory cytokine produced primarily by activated Th2 cells which is involved in B-cell maturation and differentiation. IL13 upregulates CD23 and MHC class II expression and promotes IgE isotype switching in B cells; it downregulates macrophage activity, inhibiting production of pro-inflammatory cytokines and chemokines.

Molecular pathology
IL-13 plays a central in the pathogenesis of allergen-induced asthma by IgE- and eosinophil-independent mechanisms.

interleukin

(in?ter-loo'kin),

IL

A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation

interleukin-1

Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor

interleukin-1-beta

Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin

interleukin-2

Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor

interleukin-3

Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor

interleukin-4

Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II

interleukin-5

Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil

interleukin-6

Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine

interleukin-7

Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor

interleukin-8

Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.

interleukin-9

Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.

interleukin-10

Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.

interleukin-11

Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor

interleukin-12

Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.

interleukin-14

Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.

interleukin-15

Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2

interleukin-16

Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.

interleukin-17

Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.

interleukin-18

Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.

interleukin-13

Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.
See also: interleukin
References in periodicals archive ?
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13. J Immunol.
Such response is supported by a high production of IL-13 and IL-10 followed by a low IL-12 production.
Serum IL-13, IL-17 and IL-18 levels were measured by using the commercial enzyme-linked immunosorbent assay (ELISA) kits (IL-13: Bender Medsystems, Vienna, Austria; IL-17: IBL, Hamburg, Germany; IL-18: Bender Medsystems, Vienna, Austria).
de Vries, "The role of IL-13 and its receptor in allergy and inflammatory responses," The Journal of Allergy and Clinical Immunity, vol.
o IL-1?, IL-1?, IL-2, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, IL-15, IL-17, IL-23, IFN-?, TNF-?, TNF-?
Significantly different levels of IFNI3 (p=0.028) and IL-13 (p=0.003) were obser ved among normoglycaemic, diabetic and pre-diabetic cases.
Based on early clinical experience with lebrikizumab, the study is designed to build on the body of evidence supporting targeting of IL-13 in atopic dermatitis by evaluating three different dosing regimens, with the objective of optimizing the clinical profile of lebrikizumab and establishing the dosing regimen for a potential Phase 3 program.
Animals in negative control group had lowest IL-10 and IL-13 levels while positive control groups had comparatively high concentrations.
FGF-basic, GM-CSF, IP-10, IFN-[gamma], IL-1[alpha], IL-1[beta], IL-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, IL-17, KC, MIP-1-[alpha], MCP-1, MIG, and TNF-[alpha] were evaluated with the mouse cytokine magnetic 20-Plex panel (Novex[R] by Life Technologies, USA) with the immunoassay Luminex Magpix Platform (Luminex Corporation, USA), as previously described (8).
Many of the proinflammatory factors, such as interleukin (IL)-5, IL-4, IL-13, and IL-17, play important roles in the pathological processes of the maturation, activation, survival, and recruitment of eosinophils in severe asthma [Figure 1].
OVA-induced elevated levels of serum histamine, [beta]-hexosaminidase, IgE and IgG1 as well as Th2 cytokines (IL-4, IL-5, IL-13, and IL-17) in nasal lavage fluid was significantly (p < 0.05) attenuated by fisetin.
This process is characterized by a granulomatous reaction with subsequent fibrosis [6], which is dependent mainly on Th2 mediated cytokines including interleukin- (IL-) 4, IL-5, and IL-13 [79].