Also found in: Dictionary, Thesaurus, Encyclopedia.
Related to IL-12: Il-4, Il-10, IL-23


abbreviation for interleukin-12.




A type of cytokine that enables communication among leukocytes and other cells active in inflammation or the specific immune response. The result is a maximized response to a microorganism or other foreign antigen. See: cell-mediated immunity; cytokine; inflammation


Abbreviation: IL-1
A cytokine released by almost all nucleated cells that activates the growth and function of neutrophils, lymphocytes, and macrophages; promotes the release of additional mediators that influence immune responses; enhances production of cerebrospinal fluid; and modulates certain adrenal, hepatic, bone, and vascular smooth muscle cell activity. Interleukin-1 and tumor necrosis factors, whose actions are almost identical to those of IL-1, are involved in fever production and other systemic effects of inflammation. See: tumor necrosis factor


Abbreviation: IL-1-ß
A protein released by activated macrophages that stimulates B cells and thymocytes to proliferate and mature and increases the secretion of interleukin 2. It is found in high levels in the blood of patients with septic shock and in the cerebrospinal fluid of patients with meningitis.
Synonym: catabolin


Abbreviation: IL-2
A cytokine released primarily by activated CD4+ helper T lymphocytes. It is a major mediator of T cell proliferation, promotes production of other cytokines, enhances natural killer cell function, and is a cofactor for immunoglobulin secretion. Synonym: T-cell growth factor


Abbreviation: IL-3
A cytokine produced by activated T cells that promotes proliferation of bone marrow stem cells.
Synonym: mast cell growth factor; multi-colony stimulating factor


Abbreviation: IL-4
A cytokine released by activated T cells and mast cells that stimulates B and T lymphocyte production and activity, prevents macrophages from releasing monokines, and promotes mast cell, immunoglobulin E, and eosinophil activity.
Synonym: B cell growth factor; mast cell growth factor II; T-cell growth factor II


Abbreviation: IL-5
A cytokine produced by T cells, eosinophils and mast cells that acts as the primary stimulant for eosinophil production. Synonym: eosinophil colony-stimulating factor; eosinophil differentiation factor See: basophil(e); eosinophil


Abbreviation: IL-6
A lymphokine produced by many cell types, including mononuclear phagocytes, T cells, and endothelial cells. It mediates the acute phase response, enhances B cell production and differentiation to immunoglobulin-secreting plasma cells, and stimulates megakaryocyte production. Synonym: B cell stimulatory factor II; hepatocyte stimulatory factor See: acute phase reaction; lymphokine


Abbreviation: IL-7
A cytokine produced by the thymus, spleen, and bone marrow stromal cells. It stimulates growth of B-cell precursors, development of thymocytes, and activity of cytotoxic T-cells.
Synonym: lymphopoietin 1; pre-B cell growth factor


Abbreviation: IL-8
A cytokine produced by many cell types. It acts as a neutrophil chemoattractant.


Abbreviation: IL-9
A cytokine produced by T cells. Among other functions, it promotes the proliferation and multiplication of mast cells.


Abbreviation: IL-10
A cytokine derived from mononuclear phagocytes, T cells, and keratinocytes. It inhibits cytokine synthesis by macrophages, T cells, and natural killer cells, and enhances B cell growth and secretion of immunoglobulin.


Abbreviation: IL-11
A cytokine produced by bone marrow stromal cells. It mediates acute phase protein synthesis, enhances B cell growth and differentiation to plasma cells, and promotes megakaryocyte production.
Synonym: plasmocytoma stimulating factor


Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor


Abbreviation: IL-13
A cytokine produced by T cells. It induces major histocompatibility class II expression on mononuclear phagocytes and B cells, B cell proliferation, and immunoglobulin production.


Abbreviation: IL-14
A cytokine produced by T lymphocytes and follicular dendritic cells. It stimulates proliferation of activated B lymphocytes and inhibits immunoglobulin secretion from activated B lymphocytes.


Abbreviation: IL-15
A cytokine released by epithelial cells in the kidney, skeletal muscle, liver, lungs, heart, and bone marrow, which stimulates production of T cells, esp. cytotoxic T cells and natural killer cells. It can bind with interleukin-2 receptors and mimic IL-2's effects. See: interleukin-2


Abbreviation: IL-16
A cytokine produced by T lymphocytes that stimulates movement of monocytes, CD4+ T cells, and eosinophils to the area. It was previously known as lymphocyte chemoattractant factor.


Abbreviation: IL-17
A cytokine produced by memory T lymphocytes that stimulates the proliferation of T cells and the differentiation of neutrophils.


Abbreviation: IL-18
A cytokine produced by macrophages that stimulates the production of gamma interferon and other chemical mediators that enhance cell-mediated immune responses. It is similar in structure to IL-1.


Abbreviation: IL-12
A cytokine produced by mononuclear phagocytes and B cells. It induces interferon gamma production from T cells and natural killer cells, and enhances T cell and natural killer cell cytotoxicity.
Synonym: natural killer cell stimulating factor
See also: interleukin
References in periodicals archive ?
We found that garlic lectin stimulates the production of IL-12 in mouse macrophages through the activation of p38 MAPK and ERK and induces IFN-[gamma] production in spleen cells.
Ayrica farkli toplumlarda yapilan iki calismada, psoriasisdeki onemli sitokinlerden IL-12 ve IL-23'un ortak p40 subunitesini kodlayan IL12B, IL23R genlerinde polimorfizm oldu0 u gosterilmistirZ'.
IFN-[gamma] is required for IL-12 responsiveness in mice with Candida albicans infection.
Publicaciones mas recientes en murinos han sugerido un papel primordial de la subunidad compartida por la IL-12 y la IL-23, la p40, en el establecimiento de una respuesta inmune protectora contra M.
DEPE-induced NO, in the absence of particle core, causes pulmonary inflammation and lung damage and mediates the release of both IL-12 and IL-10 by AM.
To establish intra- and interassay imprecision, another set of DBSS models were enriched with the following concentrations: 125 ng/L (low) and 2000 ng/L (high) for IL-1[beta], IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12, IL-17, IL-18, IFN-[gamma], TNF-[alpha], TNF-[beta], MCP-1, MIP-1[alpha], MIP-1[beta], GM-CSF, and NT-4; 4.
Las APC y macrofagos ademas de fagocitar y presentar antigenos modulan la inmunidad especifica (29), secretando IL-12 que estimula la produccion de IFN-[gamma] y celulas TH1; por el contrario, si secretan IL-10 e IL-6 estimulan clonas Th2.
One KC-produced cytokine is IL-12 which, until recently, was believed to be produced exclusively by macrophages and B cells (Schwarz 1995).
The study is the first to demonstrate in an animal model that GVHD can be effectively treated with IL-12 gene therapy, and that this treatment does not induce acute GVHD, the researchers wrote.
Malaria investigators have been intrigued by the cytokine interleukin-12 (IL-12) because studies have shown that injections of IL-12 temporarily protect mice against infection by sporozoites.
OncoSec's lead program, ImmunoPulse IL-12, is currently in clinical development for metastatic melanoma and triple-negative breast cancer.