IL-1


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IL1B

A gene on chromosome 2q14 that encodes interleukin-1B, a cytokine produced by activated macrophages as a proprotein, which is proteolytically activated by caspase 1 (CASP1/ICE). IL-1B is a key mediator of inflammation and is involved in an array of cellular activities, including cell proliferation, differentiation and apoptosis.

IL-1

Leukocyte-activating factor An 11 kD cytokine produced by a wide range of cells; IL-1 elicits the acute phase response, acts on the CNS as a pyrogen, stimulates fibroblast, B- and T-cell proliferation and differentiation, ↑ lymphokine, collagenase and PG production, activity of NK cells against tumor targets, stimulates myocytolysis–via PGs, elicits hormone release from the pituitary, evokes the release of PMNs from the BM, and PMN degranulation, ↑ oxidase activity and hexose monophosphate shunt activity; in synovial cells, IL-1 stimulates proliferation and production of collagen, PG, and plasminogen activator IL-1 production Stimulated by various agents–eg, calcium ionophores, IFN-α, IFN-γ, lipopolysaccharides, muramyl dipeptide, aluminum hydroxide, phorbol myristate acetate, staphylococci, silica, and others; inhibited by corticosteroids, PGE2–via the cyclooxygenase pathway, suppressor T cells, and cyclosporine–which specifically inhibits T cell-induced IL-1 production IL-1 & disease IL-1 may have a role in
1. Type 1 DM, ↑ IL-1
production by macrophages in the early β-cell destructive lesions of type 1 DM.
2. ASHD–n-3 fish oils ↓ circulating IL-1.
3. Rheumatoid arthritis–IL-1 acts with substance P.

IL-1

α Therapeutic uses IL-1α is reportedly effective in accelerating recovery of platelet counts after high-dose carboplatin and may be useful in thrombocytopenia induced by chemotherapy
References in periodicals archive ?
Cominelli, "Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease: a novel mechanism of chronic intestinal inflammation," Journal of Immunology, vol.
IL-1RN allele 2 has been related to increased production of IL-1RA and IL-1[beta] and decreased the production of IL-1 a [43].
The group contributions to cohesive energy, [E.sub.coh], and molar volume by the Fedor's method (15), although apparently less accurate than those by Small, Van Krevelen, and Hoy's methods, contained a larger number of structural groups and could, as a result, be used for calculating the solubility parameter, [delta], of IL-1 that contains elements such as phosphorus.
Single nucleotide polymorphisms in intron 2 of the human interleukin-1 receptor antagonist (IL-1Ra) gene: further definition of the IL-1 R and IL-1Ra polymorphisms in North American Caucasians and Taiwanese Chinese.
Not like other members of the IL-1 family, IL-36 is mainly expressed in keratinocytes, bronchial epithelia, brain tissues, and monocytes/ macrophages [85].
IL-6 is produced by a wide range of cell types in psoriatic plaques (including keratinocytes, fibroblasts, endothelial cells, DCs, and macrophages) in response to several stimuli, such as IL-1, TNF-alpha, IL-17, and IL-36 (Figure 2) [84, 94-96].
Injecting the older cultures with daily doses of a compound that blocked the messenger RNA from producing IL-1 alpha, the team prevented the onset of cellular senescence and extended the lifespan of the cells.
IL-1[beta] and IL-18 are two proinflammatory members of the interleukin-1 (IL-1) superfamily which function as "master" cytokines in the complex network of inflammatory responses [4-6].
The protein binds strongly and specifically to cell-surface receptors that normally serve as docking sites for interleukin-1 (IL-1), a potent compound secreted by white blood cells under a variety of biological "emergencies." When IL-1 binds to its receptor, it triggers a series of reactions in surrounding cells, causing inflammation and immune hyperactivity.
forsythia on production of IL-10 was observed in patients with periodontitis carrying the genotypes CC (-590C/T) and 11 (VNTR) of the gene encoding IL-4 while the increase in the levels of IFN[gamma], IL-1 [beta], IL-6, and TNF[alpha] in patients with the same genotypes was lower (P < 0.05).
Two decades after scientists began studying the link between immunity and stress, three new reports strengthen the idea that the protein interleukin-1 (IL-1) carries regulatory signals between the two systems.