IKBKB

(redirected from IKK-beta)

IKBKB

A gene on chromosome 8p11.2 that encodes a serine kinase which plays a key role in the NF-kappa-B signalling pathway by phosphorylating inhibitors in the inhibitor/NF-kappa-B complex (comprised of 3 subunits: IKBKA (IKKalpha/IKK1), IKBKB (IKKbeta/IKK2) and IKBKG (NEMO)), causing inhibitor dissociation and NF-kappa-B activation. The NF-kappa-B signalling pathway is activated by multiple stimuli, including inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
References in periodicals archive ?
The bacterium secretes a protein called NleH1 that directs the host immune enzyme IKK-beta to alter specific immune responses.
Before the experiments, he speculated that, by preventing programmed cell death and encouraging inflammation, IKK-beta also promotes the emergence and growth of tumors.
To show the protein's role in tumor development, Karin and his team genetically engineered mice to lack the gene for IKK-beta in specific parts of their bodies.
The mice without intestinal IKK-beta had one-fourth as many tumors as did the normal mice, the researchers report in the Aug.
In the second experiment, researchers deleted IKK-beta from bone marrow cells.
White blood cells missing IKK-beta don't rush to a tumor, which therefore gets fewer nutrients and grows more slowly.
Drug companies are already working to develop IKK-beta inhibitors to cure inflammatory diseases such as rheumatoid arthritis, says Karin, "but we think [they] will be much more useful in cancer.
The anti-inflammatory drug worked by neutralizing IKK-beta, an inflammatory secretion associated with obesity, say the researchers.
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKK-beta.
found that gastric bypass patients have a decrease during the first year after surgery in a compound called IKK-beta, which is known to sabotage insulin signaling.