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The bacterium secretes a protein called NleH1 that directs the host immune enzyme IKK-beta to alter specific immune responses.
Before the experiments, he speculated that, by preventing programmed cell death and encouraging inflammation, IKK-beta also promotes the emergence and growth of tumors.
To show the protein's role in tumor development, Karin and his team genetically engineered mice to lack the gene for IKK-beta in specific parts of their bodies.
The mice without intestinal IKK-beta had one-fourth as many tumors as did the normal mice, the researchers report in the Aug.
In the second experiment, researchers deleted IKK-beta from bone marrow cells.
White blood cells missing IKK-beta don't rush to a tumor, which therefore gets fewer nutrients and grows more slowly.
Drug companies are already working to develop IKK-beta inhibitors to cure inflammatory diseases such as rheumatoid arthritis, says Karin, "but we think [they] will be much more useful in cancer.
The anti-inflammatory drug worked by neutralizing IKK-beta, an inflammatory secretion associated with obesity, say the researchers.
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKK-beta.
found that gastric bypass patients have a decrease during the first year after surgery in a compound called IKK-beta, which is known to sabotage insulin signaling.
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