IKBKB

(redirected from IKK-beta)

IKBKB

A gene on chromosome 8p11.2 that encodes a serine kinase which plays a key role in the NF-kappa-B signalling pathway by phosphorylating inhibitors in the inhibitor/NF-kappa-B complex (comprised of 3 subunits: IKBKA (IKKalpha/IKK1), IKBKB (IKKbeta/IKK2) and IKBKG (NEMO)), causing inhibitor dissociation and NF-kappa-B activation. The NF-kappa-B signalling pathway is activated by multiple stimuli, including inflammatory cytokines, bacterial or viral products, DNA damage, or other cellular stresses.
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References in periodicals archive ?
Samikannu et al., "Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-[kappa]B activity in pancreatic islets depends on oxygen availability," American Journal of Transplantation, vol.
Frantz et al., "Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB," Nature Medicine, vol.
Greten et al., "IKK-beta links inflammation to obesity-induced insulin resistance," Nature Medicine, vol.
Jiang et al., "Mutation of cysteine 46 in IKK-beta increases inflammatory responses," Oncotarget, vol.
The bacterium secretes a protein called NleH1 that directs the host immune enzyme IKK-beta to alter specific immune responses.
In two experiments, researchers at the University of California, San Diego showed that deactivating a protein called I-kappa-B kinase beta (IKK-beta) inside cells stops cancer progression in its tracks.
Before the experiments, he speculated that, by preventing programmed cell death and encouraging inflammation, IKK-beta also promotes the emergence and growth of tumors.
To show the protein's role in tumor development, Karin and his team genetically engineered mice to lack the gene for IKK-beta in specific parts of their bodies.
The mice without intestinal IKK-beta had one-fourth as many tumors as did the normal mice, the researchers report in the Aug.
In the second experiment, researchers deleted IKK-beta from bone marrow cells.
White blood cells missing IKK-beta don't rush to a tumor, which therefore gets fewer nutrients and grows more slowly.
The anti-inflammatory drug worked by neutralizing IKK-beta, an inflammatory secretion associated with obesity, say the researchers.