IKBKE


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IKBKE

A gene on chromosome 1q32.1 that encodes a protein which phosphorylates inhibitors of NF-kappa-B, leading to the dissociation of the inhibitor/NF-kappa-B complex and degradation of the inhibitor. IKBKE protects cells against DNA-damage-induced cell death and is highly expressed in the spleen. It may play a role in the immune response.
References in periodicals archive ?
STAT3 directly binds to the IKBKE promoter and induces IKBKE transcription," he added.
Armed with this knowledge, interventions targeting the IKBKE pathway could be developed," said Cheng.
Cheng and his colleagues found that when STAT3 induces IKBKE expression, IKBKE's expression induces chemotherapy resistance.
With IKBKE blocked, the cancerous cells slowly withered and died, indicating that the cells depended on it for survival.
The cancerous cells contained a mutation that produced 5 to 10 extra copies of IKBKE, but it remains unclear exactly how that mutation happens or what puts a person at risk of it.