This signaling relies on the recruitment of many regulatory subunits (TRAF2, TRAF5, TRAF6, and NEMO), which allows the phosphorylation of immune transcription factors via IKBKE, TBK1, and IKK protein kinases, leading to their nuclear translocation and the production of type 1 IFN with subsequent expression of ISGs (Figure 2) [29-34].
Initially, LGP2 was proposed as a negative feedback regulator of the RLR pathway that would act by sequestering vRNA from RIG-I  or by displacing IKBKE from MAVS in order to terminate IRF3-dependent antiviral signaling .
Aref et al., "Targeting an IKBKE
cytokine network impairs triple-negative breast cancer growth," The Journal of Clinical Investigation, vol.
Washington, Feb 10 ( ANI ): Researchers have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers.
Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance.
The high percentage makes the malfunctioning of this gene, called I-kappa-B kinase epsilon (IKBKE), one of the most widespread genetic traits among breast cancer patients, says William C.
IKBKE is normally active only in immune system cells, where it helps trigger a response to invading viruses.
These genes are involved in immune response (CD97, FYB, CXCL1, IKBKE, and CCR1), inflammatory response (CD97, CXCL1, C3AR1, CCR1, and LYZ), homeostasis (C3AR1, CCR1, PLN, CCL19, and PPT1), and other processes (JAK/STAT, SOCS, c-IAP1, c-IAP2, XIAP, PI3K/Akt/mTOR, SAPK/ MAPK, and IL-20-induced TNF-[alpha], IL-1[beta], MMP-1, and MMP-13) [44,46].
These genes are Akt1, C3ar1, Ccl19, Ccr1, Cd97, Cxcl1, Fyb, Ifi202b, Ifi203, Ifi204, Ifi205, Ikbke, Lyz1, Map3k13, Mapk10, Mapk10, Mapk13, Pln, Ppt1, Socs1, and Xiap.
Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE
), is a target of miR-155, and it has been suggested that miR-155 may be a protective factor against inflammation by attenuating expression of IKBKE