IKBKE


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IKBKE

A gene on chromosome 1q32.1 that encodes a protein which phosphorylates inhibitors of NF-kappa-B, leading to the dissociation of the inhibitor/NF-kappa-B complex and degradation of the inhibitor. IKBKE protects cells against DNA-damage-induced cell death and is highly expressed in the spleen. It may play a role in the immune response.
References in periodicals archive ?
Washington, Feb 10 ( ANI ): Researchers have discovered that the immune response regulator IKBKE (serine/threonine kinase) plays two roles in tobacco-related non-small cell lung cancers.
Tobacco carcinogens induce IKBKE and, in turn, IKBKE induces chemotherapy resistance.
In our study, we demonstrated that IKBKE is a STAT 3 target gene and is induced by tobacco.
IKBKE is normally active only in immune system cells, where it helps trigger a response to invading viruses.
Of the genes, only IKBKE showed elevated activity, and this occurred in 30 percent of the patients' cancers.