NFKBIB

(redirected from IKBB)
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NFKBIB

A gene on chromosome 19q13.1 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
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Protein Mass, Genes Structure Knockout phenotype kDa p65 (ReIA) 65 relA 551 Embryonic death ReIB 66 relB 582 Thymic atrophy c-Rel 68 c-rel 587 Reduced cytokine production from T cell and macrophage p50/p105 50/105 nfkbl 969 Compromised B-cell reaction p52/p100 52/100 nfkb2 940 Compromised B-cell reaction I[kappa]B[alpha] 37 med-3 317 Multifocal inflammation I[kappa]B[beta] 41 ikbb 359 Not determined I[kappa]B[epsilon] 45 ikbe 361 Not determined Bcl3 45 bc13 421 Deficiency in humoral response * RHD, Rel-homology domain.