NFKBIA

(redirected from IKBA)
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NFKBIA

A gene on chromosome 14q132 that encodes an I-kappa-B protein that inhibits the multimeric NFKB complex by trapping it in the cytoplasm. Kinases IKBKA or IKBKB phosphorylate NFKBIA’s serine residues, marking them for destruction via the ubiquination pathway, allowing activation of the NFKB complex which, once activated, translocates to the nucleus, binds DNA and activates transcription.
References in periodicals archive ?
The mechanism by which berberine modulates -germline transcript expression might be through regulating the phosphorylated IkBa level and the expressions of signal transducer and activator of transcription-3 and T-box transcription factor TBX21.
principal de IkBa es la de retener a NFkB en el citoplasma de celulas no
Vakia uc seriye hakimi ikba edildi fakat bunlarin da maaslari Kibris evkafi islamiye sandigina tahvil edildi.
Las formas inactivas de [NF-.sub.K]B conocidas como IkBa y IkBb son fosforiladas por quinasas IkB, que inducen la traslocacion de [NF-.sub.K]B dentro del nucleo de la celula hospedera, donde regula la expresion de citoquinas proinflamatorias (Hauf et al., 1994).
Cattinair in Pont de Roide, France, designed its Roto clean spraying machine to require less solvent, and generate less waste, while finishing wooden parts for Roche Bobois and IKBA furniture in Europe and playground equipment made by Rainbow Play Systems in Brookings, S.D.
As shown in Figure 4, after LPS stimulation, the expression of NOD1, RIP2, and NF-[kappa]B was dramatically higher compared with the control group, while the expression of IKBa was lower.
Naumann, "p97/VCP promotes Cullin-RING-ubiquitin-ligase /proteasome-dependent degradation of I[kappa]B[alpha] and the preceding liberation of RelA from ubiquitinated IKBa," Journal of Cellular and Molecular Medicine, vol.
[LTC.sub.4] induces the phosphorylation of NF-kB p65, activates the complex NF-kB p50-p66 [155], and via the CysLT2 receptor induces the phosphorylation of IkBa by involving protein kinase family enzymes [156].
Phosphorylated IkB[alpha] and IkBa antibodies were purchased from Santa Cruz (Shanghai, China).
Since IkBa is phosphorylated after stimulation by LPS, followed by the release of the NF-[kappa]B-p65 protein into the nucleus, and promotes the production of proinflammatory cytokines, we next evaluated the effect of Andrographolide on the inhibition of LPS-induced NF-[kappa]B and MAPK pathways by a western blot.
Moreover, the NF-[kappa]B pathway plays a major role in promoting the release of cytokines; changes to endogenous NF-[kappa]B can be measured by the IKBa degradation, which begins degradation when NF-[kappa]B is activated [27].
Similarly, the inhibitor of oxidation N-acetyl-L-cysteine (NAC) effectively downregulated the levels of IkBa and IKKa/b phosphorylation, decreased p65 nuclear translocation, and inhibited NF-[kappa]B activity.