IGF1R

(redirected from IGFR)
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IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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When r [greater than or equal to] [v.sub.L]/[v.sub.H] and G(x) is an IGFR distribution, the firm's profit function has a maximum value point.
If G(x) is an IGFR distribution, a firm's optimal solution when a price commitment is provided before the selling season under a two-period QR strategy has three situations:
If G(X) is an IGFR distribution, the right-hand side of (A.1) decreases with [p.sub.H], and (A.2) decreases with [p.sub.L].
If G(x) is an IGFR distribution, the right-hand side of (A.11) decreases with [p.sub.H], and (A.12) decreases with [p.sub.L].
These binding proteins regulate the amount of free IGF available to bind to IGF-receptors (IGFRs) on cells.
For both the Cystatin C assay and iGFR procedure, details are described in the online expanded Methods section [see the Data Supplement that accompanies the online version of this article at http://www.clinchem.
Reciprocals of Cystatin C and creatinine allowed the linearization of the curvilinear relationship between iGFR and each serum marker.
In creating ROC curves, we used 3 cutoffs for iGFR: 60, 75, and 90 mL * [min.sup.-1] * (1.73 [m.sup.2).sup.-1].
Albuminuria correlated inversely with decreasing iGFR (n = 288, r = -0.439, P <0.0001).
CORRELATIONS BETWEEN ENDOGENOUS PARAMETERS OF RENAL FUNCTION AND IGFR
Abbreviations APC: Allophycocyanin BM: Bone marrow CCK-8: Cell-counting kit-8 CD1K: Cyclin D1-dependent kinase ERK: Extracellular signal-regulated kinase FBS: Fetal bovine serum FITC: Fluorescein isothiocyanate GAPDH: Glyceraldehyde-3-phosphate dehydrogenase IGFR: Insulin-like growth factor receptor IR: Insulin receptor MSC: Mesenchymal stem cells PBS: Phosphate-buffered saline PE: Phycoerythrin PI: Propidium iodide Rb: Retinoblastoma protein SCM: Serum-containing media SFM: Serum-free medium UCM: Umbilical cord matrix.
Inhibition of IGFR with the inhibitor NT157 caused a substantial reduction in tumor burden by affecting cancer cells, cancer-associated fibroblasts (CAF), and myeloid cells.