IGF1R

(redirected from IGFR)
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IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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IGFR Type 1 diabetes (n = 125) Reduced GFR Normal GFR <90 (n = 61) >90 (n = 64) 1/serum cystatin C, mg/L r = 0.
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