IGF1R

(redirected from IGFIR)

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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Santamaria et al., "Protein tyrosine phosphatase 1B modulates GSK3b/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity," Cell Death and Disease, vol.
Wang et al., "Elevated IGFIR expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer," BMC Cancer, vol.
IGF-I is a complex system of peptide hormones that bind to the insulin-like growth factor I receptor (IGFIR), in order to activate their intrinsic tyrosine kinase domain activities (Denley et al., 2005).
Al silenciar el receptor IGFIR se encontro una atenuacion en los efectos proliferativos de IGF-I e IGF-II, en comparacion con las celulas no silenciadas (Freyre, 2010), mientras que al silenciar el receptor de insulina, se observo la sobre-activacion de la via MAPK y el incremento en los efectos proliferativos del IGF-I evaluados por medio del metodo colorimetrico MTT.
Activation of the IGF-IR occurs following IGF-I binding to the [alpha]-subunit of the IGFIR on epithelial cells, leading to autophosphorylation of the [beta]-subunit by an intrinsic tyrosine kinase.
(25) Development of an insulin-like growth factor analogue (LONG R3IGF-I) that acts directly, at a much higher potency, on the IGFIR has been shown to be equivalent to or outperform insulin and IGF-I in supporting CHO cell growth and productivity.
DNA from female centarians with heights below the mean for that population was then screened for any possible genetic variations in the IGF1 and IGFIR genes.