Santamaria et al., "Protein tyrosine phosphatase 1B modulates GSK3b/Nrf2 and IGFIR
signaling pathways in acetaminophen-induced hepatotoxicity," Cell Death and Disease, vol.
Wang et al., "Elevated IGFIR
expression regulating VEGF and VEGF-C predicts lymph node metastasis in human colorectal cancer," BMC Cancer, vol.
IGF-I is a complex system of peptide hormones that bind to the insulin-like growth factor I receptor (IGFIR
), in order to activate their intrinsic tyrosine kinase domain activities (Denley et al., 2005).
Activation of the IGF-IR occurs following IGF-I binding to the [alpha]-subunit of the IGFIR
on epithelial cells, leading to autophosphorylation of the [beta]-subunit by an intrinsic tyrosine kinase.
(25) Development of an insulin-like growth factor analogue (LONG R3IGF-I) that acts directly, at a much higher potency, on the IGFIR
has been shown to be equivalent to or outperform insulin and IGF-I in supporting CHO cell growth and productivity.
DNA from female centarians with heights below the mean for that population was then screened for any possible genetic variations in the IGF1 and IGFIR