IGFBP7


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IGFBP7

A gene on chromosome 4q12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family which that insulin-like growth factors I and II and circulates in the plasma. IGFBP7 stimulates prostacyclin production and cell adhesion.

Molecular pathology
A variant of IGFBP7 has been associated with retinal arterial macroaneurysm.
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Those markers include HMGA1 and 2, CD163, ApoD, tenascin, S100A6, MMP2 and 11, IGFBP7, cathepsin K, and D2-40.
Urinary Biomarkers TIMP-2 and IGFBP7 Early predict acute kidney injury after major surgery.
72) In another study, (73) in a series of 14 differentially expressed genes, 8 were upregulated: CFB (complement factor B), FTL (ferritin, light polypeptide), IGFBP7 (insulin-like growth factor-binding protein 7), RARRES1 (retinoic acid receptor responder 1), RARRES2 (retinoic acid receptor responder 2), RBP1 (retinol-binding protein 1), SAT (spermidine/ spermine N1-acetyltransferase), and TXN (thioredoxin), while 6 were down-regulated: ALOX5AP (arachidonate 5-lipoxygenase-activating protein), CLNS1A (chloride channel nucleotide-sensitive 1A), EIF4A2 (eukaryotic translation initiation factor 4A2), ELK3 (ETS-domain protein, SRF accessory protein 2), DF2/REQ (apoptosis response zinc finger gene), and SYPL (synaptophysin-like protein).