IGFBP6


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IGFBP6

A gene on chromosome 12q13 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP6 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
References in periodicals archive ?
In L6E9 skeletal myoblasts, IGFBP-4 and IGFBP-6 were accumulated during myogenesis, with IGFBP-4, and not IGFBP6, inhibiting IGF-1 induced muscle differentiation [40].
The increase in Pax3/7 could be due to the presence of a greater availability of extracellular IGF-2 (Supplementary Figure 7B), which is being recruited to the commitment process or could be due to actions independent of IGFBP6. In contrast, the muscle differentiation markers (MyoD, MyoG, and MHC) were all reduced after IGFBP-6 knockdown, suggesting that IGFBP-6 is required for the muscle differentiation process.
(b) IGFBP6 secretion into conditioned media was increased with both IGF-1 (days 1 and 3) and IGF-2 (days 1 to 7) compared to controls.