Multiple ALK fusion partner genes have been recognized including TPM3, SEC31, IGFBP5
, TIMP3, THBS1, and DES.
Insulin-like growth factor-binding protein 5 (IGFBP5
) compromises survival, growth, muscle development, and fertility in mice.
Using this procedure, we found similar gene expression profiles for INHA, IGFBP5
, BMPR1B, BMP2, INSIG, PTGS2, LOC102181730 and LOC102184274, which indicated the high credibility of these genes in transcript abundance; however, some factors in the RNA-seq results, including BAX, LOC102183322, and BCL2, were inconsistent (Fig.
It can induce tumor stem cell-like phenotypes and characteristics and upregulate the expression levels of cancer stem cell markers CXCR4, IGFBP5
, CD133, and AL-DH1.
ACOT2 CFD GCSH LACTB RASSF2 ACY1 CITED2 GJA4 LRP8 RSAD2 ADAMTS9 CRYAB GSTP1 LRRC58 RUNX2 ALCAM CTGF HACD4 NFKB1 SLC26A7 ANKRD9 CXCL1 HSD17B1 NR3C2 SMIM22 ARHGAP22 DGAT2 IGFBP5
NRIP3 SPARC BHLHE40 EGR1 IGFBP7 NUP107 STS BRAF EIF4E IRGQ OPRK1 TAZ CAMK1G ENPP1 JUN OSTALPHA TEKT4 CAMKK2 F10 KCNJ15 PBLD TG CD47 FAM13A KCNJ16 POMT1 TMEM140 CDA FGFR2 KCNK1 PRR5L TRIB1 CDH16 FOXE1 KRT14 RAB17 WBP2 CDH16 GALK2 KRT7 RASL10A WNT4
Genes P value COL4A1 3.17E-08 PCDH17 7.47E-08 PECAM1 2.07E-07 IGFBP5
2.73E-07 CAV1 2.75E-07 KCNJ8 3.49E-07 PIK3R3 3.53E-07 LCN2 3.77E-07 COL6A3 4.13E-07 COL4A2 4.78E-07 HEG1 5.51E-07 CD93 6.32E-07 ADAM9 6.36E-07 RIPK2 9.92E-07 AMN 1.11E-06 ACVR1 1.11E-06 CALU 1.17E-06 CXCL6 1.32E-06 TMEM158 1.63E-06 TIMP3 1.70E-06 Table 2.
Medhamurthy, "Analysis of 17[beta]-estradiol ([E.sub.2]) role in the regulation of corpus luteum function in pregnant rats: involvement of IGFBP5
in the [E.sub.2]-mediated actions," Reproductive Biology and Endocrinology, vol.
Bladder cancer gene panels used in the Cxbladder Detect urinary test were also examined (CDK1, MDK, IGFBP5
, HOXA13 and CXCR2).
Ten are of known function [GJA1, ITGB3, collagen type I alpha 1 (COL1A1), IGFBP5
, MMP2, myosin light polypeptide kinase (MYLK), GATA binding protein 6 (GATA6), chemokine (C-C motif) ligand 2 (CCL2), protein kinase C alpha (PRKCA), and nudeoporin (NUP88)], and one has unknown function.
Jia et al., "Demethylation of IGFBP5
by histone demethylase KDM6B promotes mesenchymal stem cell-mediated periodontal tissue regeneration by enhancing osteogenic differentiation and anti-inflammation potentials," Stem Cells, vol.
Many nsSNPs were also found in meat quality related genes such as ankyrin 1 (ANK1), stearoyl-CoA desaturase (SCD), microtubule-associated protein 1B (MAP1B), NCK-associated protein 1-like (NCKAP1L), insulin-like growth factor binding protein 5 (IGFBP5
) and mitochondrial poly (A) polymerase (MTPAP) (Table 4).
(48) In an MMTV-Wntl mouse mammary tumor model, regression of mammary tumors by Wnt inhibitor Fzd8CRD was associated with an acute and strong induction of IGF-binding protein IGFBP5
, another member of the IGF-binding protein family and an antagonist of IGF signaling that mediates involution of the mammary gland in females after offspring are weaned.