IGFBP4


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IGFBP4

A gene on chromosome 17q12-q21.1 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP4 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
References in periodicals archive ?
The identification of IGFBP4 as a risk marker for stroke in postmenopausal women also appears to be a novel finding.
In the peripheral circulation of preeclamptic pregnancies compared with non-preeclamptic pregnancies, MIG and MIP1[delta]/3[alpha] (innate immunity) were significantly increased, TGF[beta]1/[beta]3 and TNF[beta] (adaptive immunity) were significantly decreased, and other molecules (CNTF, EGF, IGFBP4, and BMP6) were significantly increased (n = 10 vs 10; Fig.