IGFBP4 | definition of IGFBP4 by Medical dictionary
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IGFBP4 A gene on chromosome 17q12-q21.1 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP4 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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References in periodicals archive
The identification of IGFBP4
as a risk marker for stroke in postmenopausal women also appears to be a novel finding.
Adhesion molecules/ growth factors, including ciliary neurotropic factor (CNTF), epidermal growth factor (EGF), intercellular adhesion molecule (ICAM1), insulin-like growth factor binding proteins (IGFBP4
), and bone morphogenetics protein (BMP6), were also stimulated in the preeclamptic placenta (Fig.
On the other hand, IGFBP3 and IGFBP4
can inhibit the potentiation effect of IGF-2 on BMP9-induced ALP activity and matrix mineralization in MSCs .
Assignment of porcine insulin-like growth factor-binding protein-4 (IGFBP4
) to SSC12 by fluorescence in situ hybridization and radiation hybrid mapping.