IGFBP3


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IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Gene Sequence of primers Length of Tm ([degrees]C) amplicon (bp) * ([dagger]) IGF1 Forward: 5'- 221 77.6 TGCTTCCGGAGCTGTGATC-3' Reverse: 5'-GATCCTGCGGTGG- CATGTCACTCTTCACT-3' IGF1R Forward: 187 77.4 5'-ACGCCAATAAGTTCGT- CCACAGAGACCT-3' Reverse: 5'-GAAGACTCCATCC- TTGAGGGACTCAG-3' IGFBP3 Forward: 102 82.4 5'-GCTACAGCATGCAG- AGCAAGT-3' Reverse: 5'-CAGCTGCTGGTCA- TGTCCTT-3' GAPDH Forward: 226 80.0 5'-GAAGGTGAAGGT- CGGAGTC-3' Reverse: 5'-GAAGATGGTGA- TGGGATTC-3' * bp: base pairs.
Genes downregulated by cisplatin include those that localize to the proximal tubules (Odc1, Oat, G6pc, Kap) and those that encode growth factors or their binding proteins (Egf, Ngfg, Igfbp3, Ghr).
However, the effect of GH therapy on the final height is substantially variable depending on several clinical and genetic factors such as polymorphisms related with GH receptor and/or IGFBP3 gene, young age, and bone age delay at the start of GH treatment.
By impairing this complex regulatory physiology, low portal insulin concentrations, documented in children with T1D, result in GH hypersecretion, low circulating levels of IGF-I and IGFBP3, and high circulating levels of IGFBP-1.
Colostrum supplementation increased IGF binding protein-3 (IGFBP3) in both sham and short bowel resectioned pigs but increased IGF-I in only the pigs undergoing bowel resectioning (Pereira-Fantini et al., 2008).
Consistent with these findings, HIF-l[alpha]-inducible genes, including the insulin-like growth factor binding protein (IGFBP3) and GLUT1, were up-regulated following nickel exposure (Figure 1) (Minet et al.
The researchers were also asked to enter to the system laboratory assessments including hormonal [thyroxine, thyroid-stimulating hormone (TSH), insulin-like growth factor 1 (IGF1), IGF-binding protein 3 (IGFBP3)] test results, GH stimulation tests, and bone age.
Association analysis between insulin-like growth factor binding protein 3 (IGFBP3) polymorphisms and carcass traits in cattle.
Plasma IGF-I forms ternary complexes by associating with IGFBP3 or -5 and ALS.
ABSTRACT : The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity.