IGFBP3

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IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.

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ADAM1bca12

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Gene Sequence of primers Length of Tm ([degrees]C) amplicon (bp) * ([dagger]) IGF1 Forward: 5'- 221 77.6 TGCTTCCGGAGCTGTGATC-3' Reverse: 5'-GATCCTGCGGTGG- CATGTCACTCTTCACT-3' IGF1R Forward: 187 77.4 5'-ACGCCAATAAGTTCGT- CCACAGAGACCT-3' Reverse: 5'-GAAGACTCCATCC- TTGAGGGACTCAG-3' IGFBP3 Forward: 102 82.4 5'-GCTACAGCATGCAG- AGCAAGT-3' Reverse: 5'-CAGCTGCTGGTCA- TGTCCTT-3' GAPDH Forward: 226 80.0 5'-GAAGGTGAAGGT- CGGAGTC-3' Reverse: 5'-GAAGATGGTGA- TGGGATTC-3' * bp: base pairs.

Gene expression of IGF1, IGF1R, and IGFBP3 in epiretinal membranes of patients with proliferative diabetic retinopathy: preliminary study

Igfbp3 modulates cell proliferation in the hair follicle.

DNA polymorphism of insulin-like growth factor-binding protein-3 gene and its association with cashmere traits in cashmere goats

The levels of IGF-1 and IGFBP3 were 56 ng/mL (<-3 SD) and 1848 ng/mL (-3 SD), respectively.

Long-Term Follow-up of a Case with Proprotein Convertase 1/3 Deficiency: Transient Diabetes Mellitus with Intervening Diabetic Ketoacidosis During Growth Hormone Therapy

Genes downregulated by cisplatin include those that localize to the proximal tubules (Odc1, Oat, G6pc, Kap) and those that encode growth factors or their binding proteins (Egf, Ngfg, Igfbp3, Ghr).

Identification of platform-independent gene expression markers of cisplatin nephrotoxicity

However, the effect of GH therapy on the final height is substantially variable depending on several clinical and genetic factors such as polymorphisms related with GH receptor and/or IGFBP3 gene, young age, and bone age delay at the start of GH treatment.

A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey

By impairing this complex regulatory physiology, low portal insulin concentrations, documented in children with T1D, result in GH hypersecretion, low circulating levels of IGF-I and IGFBP3, and high circulating levels of IGFBP-1.

Growth abnormalities in children with type 1 diabetes, juvenile chronic arthritis, and asthma

Colostrum supplementation increased IGF binding protein-3 (IGFBP3) in both sham and short bowel resectioned pigs but increased IGF-I in only the pigs undergoing bowel resectioning (Pereira-Fantini et al., 2008).

Colostrum protein isolate increases gut and whole body growth and plasma IGF-I in neonatal pigs

Consistent with these findings, HIF-l[alpha]-inducible genes, including the insulin-like growth factor binding protein (IGFBP3) and GLUT1, were up-regulated following nickel exposure (Figure 1) (Minet et al.

Genomic and proteomic profiling of responses to toxic metals in human lung cells. (Article)

The researchers were also asked to enter to the system laboratory assessments including hormonal [thyroxine, thyroid-stimulating hormone (TSH), insulin-like growth factor 1 (IGF1), IGF-binding protein 3 (IGFBP3)] test results, GH stimulation tests, and bone age.

The Growth Characteristics of Patients with Noonan Syndrome: Results of Three Years of Growth Hormone Treatment: A Nationwide Multicenter Study

Association analysis between insulin-like growth factor binding protein 3 (IGFBP3) polymorphisms and carcass traits in cattle.

Estimation of interaction effects among nucleotide sequence variants in animal genomes

Plasma IGF-I forms ternary complexes by associating with IGFBP3 or -5 and ALS.

Growth hormone signaling in the regulation of acid labile subunit

ABSTRACT : The insulin-like growth factor binding protein 3 (IGFBP3) has been investigated as a candidate gene for growth promoting effects in beef cattle and a modulator of IGF bioactivity.

Association analysis between insulin-like growth factor binding protein 3 (IGFBP3) polymorphisms and carcass traits in cattle