enhances adipogenic differentiation potentials of mesenchymal stem cells from Wharton's jelly of the umbilical cord via JNK and Akt signaling pathways.
Some of the upregulated genes comprised genes with important functions in the immune response and proliferation, such as claudin 4 (CLDN4), orosomucoid 1 (ORM1), insulin-like growth factor binding protein 2 (IGFBP2
), cytochrome P450, family 26, subfamily A, polypeptide 1 (CYP26A1), and growth arrest-specific 1 (GAS1).
Furthermore, diagnosis of PDAC using the combination of CA19-9, IGFBP2
, and IGFBP3 is significantly more effective than CA19-9 alone.
The present RNA-Seq data revealed enhanced expression of several players in the IGF signaling pathway, including IGFBP1 (GeneID 3484) across all treatments, IGFBP2
(GeneID 3485) by E2, and IGFBP3 (GeneID 3486) by E2 and DPN.
Wysocki et al., "Antidiabetic effects of IGFBP2
, a leptin-regulated gene," Cell Metabolism, vol.
Kim, "The role of insulin-like growth factor binding protein 2 (IGFBP2
) in the regulation of corneal fibroblast differentiation," Investigative Ophthalmology & Visual Science, vol.
Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2
, and ELF3 with epithelial differentiation.
P Holly et al., "Loss of PTEN expression is associated with IGFBP2
expression, younger age, and late stage in triple-negative breast cancer," The American Journal of Clinical Pathology, vol.
The selected genes include four encoding signaling proteins (FGFR3 encoding fibroblast growth factor receptor 3, EPHB2 encoding ephrin type-B receptor 2, GREM1 encoding gremlin 1, and IGFBP2
encoding insulin-like growth factor binding protein 2), two extracellular matrix genes (COL3A1 encoding collagen, type III, alpha 1, and TNC encoding cytotactin or tenascin-C), and two metabolic genes (ACBD7 encoding acyl-CoA-binding domain containing 7 and SCD encoding stearoyl-CoA desaturase).
The researchers found that the hormone controls the activity of a gene known as IGFBP2
in the liver, which has antidiabetic effects in animals and could have similar therapeutic effect in humans.
found that the oncofetal insulin-like growth factor 2 mRNA-binding protein 2 (IMP2, IGFBP2
), which plays a role in oxidative phosphorylation, is a key regulator in proneural GSCs and correlates with poor prognosis .