ELISA Measurement of IGFBP1. The serum levels of IGFBP1 were determined using a commercially available human IGFBP1 ELISA kit from RayBiotech (USA).
Correlations between IGFBP1 levels and severity of coronary artery lesions were assessed by calculating Spearman correlation coefficients.
Patient Characteristics and Circulating Level of IGFBP1. In the 112 enrolled patients with unstable angina, 67 patients were diagnosed by CAG with critical CAD and 45 with noncritical CAD.
Considering that the IGF-1 and IGFBP-1 in the blood are predominately produced in the liver and kidney, the expression levels of IGF1 and IGFBP1 between the yak and cattle were compared.
Distinct post-transcriptional regulation of Igfbp1 gene by hypoxia in lowland mouse and Qinghai-Tibet plateau root vole Microtus oeconomus.
Progesterone regulates FGF10, MET, IGFBP1
, and IGFBP3 in the endometrium of the ovine uterus.
These included the Igfbp1
, GOs2, Fasn, Cyp4a14, Scd1, Hmgcr, Gk and Fabp2 genes.
(a) microRNA miR-516-5p miR-517 * miR-526a miR-525 miR-520a * Number of 349 179 212 340 352 predicted target genes Unique target genes Shared with miR-525 CCR2 FAS BCAP29 TOX ACVR2B CD109 IL6ST CD24 AHSA2 CD1A IL9R CD302 ATRN DNAJC25 IRAK3 CFLAR CD2 FLT1 LILRA2 DNAJC21 CD300LB IL17RE MTDH HSP90AA1 CD46 IRAK1 PAPPA IGFBP1
CD93 LILRB5 TLR2 HSF5 PDCD6IP TNFRSF19 IGF1R SOCS2 TNFSF15 IL10RA TRAF6 MMD2 PPARA TLR7 VSIG4 All the targets were predicted by a bioinformatics tool MirTarget2 using miRDB online database.
The IGF system consists of ligands (insulin, IGF-I and IGF-II), receptors (insulin-R, IGF-R1 and IGF-R2), six IGF binding proteins (IGFBP1
to 6) and proteases that may alter IGFBPs and change IGF and IGFBPs affinities (Giudice et al., 1990).
Patients with INSR mutation differ biochemically from patients with more common insulin resistance associated with the metabolic syndrome by having high levels of adiponectin, sex-hormone-binding globulin (SHBG), and insulin-like growth factor-binding protein 1 (IGFBP1) .
Patients with insulin receptor defects also differ biochemically from other types of insulin resistance by displaying elevated adiponectin, IGFBP1, and SHBG, which are all commonly suppressed in common insulin resistance or lipodystrophy-associated severe insulin resistance.
The IGF family is comprised of ligands: IGF1, IGF2, insulin; six binding proteins (IGFBP1
through -6); and cell surface receptors, includingIGF1R, IGF2R, and insulin receptors .