IGFBP1


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IGFBP1

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP1 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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In this proposal I will address this hypothesis by employing state of the art studies in cells and novel gene modified mice to unravel the molecular basis of the protective effects of IGFBP1 and to investigate the possibility of exploiting the IGF-IGFBP axis to prevent cardiovascular disease in the setting of diabetes and obesity.
A decrease in IGF-1 and an increase in IGFBP1 in arsenic-exposed livers are similar to findings with the nongenotoxic model carcinogens such as oxazepam and Wyeth-14,643 (Iida et al.
Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus.