IGFBP7

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IGFBP7

A gene on chromosome 4q12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family which that insulin-like growth factors I and II and circulates in the plasma. IGFBP7 stimulates prostacyclin production and cell adhesion.

Molecular pathology
A variant of IGFBP7 has been associated with retinal arterial macroaneurysm.
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(11) The test measures two urinary proteins, tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7), to identify patients at increased risk of developing moderate-severe AKI in the next 12 hours.
TIMP-2 and IGFBP-7 are soluble proteins expressed in the kidney that are known to participate in the response to a variety of tissue insults that cause AKI such as inflammation, oxidative stress, drugs, and toxins.
Recently, tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP-7) have been investigated as predictive urine biomarkers of AKI in high-risk patients [80, 81].
Novel AKI-specific biomarkers available are NGAL, KIM-1, and levels of TIMP-2 x IGFBP-7 with accumulating evidence being in favor of their diagnostic and prognostic value.
The test uses fluorescence immunoassay technology to identify and assess two biomarkers of AKI, namely tissue inhibitor of metalloproteinase 2 (TIMP-2) and insulin-like growth factor binding protein 7(IGFBP-7), in human urine.
TIMP-2 and IGFBP-7 are new markers and look very good for risk stratification.
So far, five IGFBPs (IGFBP-1, 2, 3, 4, 5) and low-affinity IGFBP-7 are identified in NCBI chicken genome (build 2.1), since no IGFBP-6 gene homologue has been identified for chickens.
Investigators in the study used Astute Medical, Inc.'s NephroCheck Test to obtain measurements of the two biomarkers, tissue inhibitor of metalloproteinase 2 (TIM P-2) and insulin-like growth factor binding protein 7 (IGFBP-7).
The IGFBP family, a crucial component of the IGF system, consists of high-affinity (IGFBP-1 to -6) and low-affinity (IGFBP-7 to -10) binding proteins (Hwa and Rosenfeld, 1999).
In this study, we used real-time quantitative PCR to assess IGF-I, IGF-II, IGF-IR, IGFBP-2, IGFBP-5, IGFBP-7, and IGFBP-3 mRNA expression in the breast muscle of slow-growing Langshan (LS) layer and rapidly-growing Arbor Acres (AA) broiler chickens.
This unmet clinical need is now being addressed with the introduction of an assay measuring the urinary concentration of two proteins, tissue inhibitor of metalloproteinase-2 (TTMP-2) and insulin-like growth factor binding protein-7 (IGFBP-7).
TIMP-2 and IGFBP-7 are soluble proteins expressed in the kidney and are known to be involved in the response to a wide variety of tissue insults that can cause AKI such as inflammation, oxidative stress, drugs, and toxins.