IGFBP5

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IGFBP5

A gene on chromosome 2q33-q36 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP5 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
References in periodicals archive ?
Expression of IGFBP-2, IGFBP-5, IGFBP-7 and IGFBP-3 genes in the breast muscle tissue during development
IGFBP-5 is the most conserved of the IGFBPs (James et al.
Our results showed no difference in IGFBP-5 mRNA expression (p>0.
IGFBP-5 preferentially binds IGF-II (Clemmons et al.
On the other hand, IGFBP-3 and IGFBP-5 are much lower in older individuals than younger ones (34).
Evidence that human bone cells in culture produce IGFBP-4 and IGFBP-5 proteases.
Serum IGFBP-4 and IGFBP-5 in aging and age-associated diseases.
Age-related changes in IGFBP-4 and IGFBP-5 in human serum and bone: implications for bone loss with aging.
This complex consists of one molecule each of IGF-I or IGF-II, IGF-binding protein (IGFBP)-3 or IGFBP-5 and an acid labile subunit (ALS).
ALS is also capable of binding binary complexes of IGFs and IGFBP-5 (Twigg and Baxter, 1998).