IGFBP3

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IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Therefore, the purpose of this study was to compare changes in growth related hormones (GH, IGF-1 and IGFBP-3) between elite youth soccer players belonging to youth national team and non-athletic controls over a 2-year period.
In fact, circulating IGF-I, primarily produced by the liver, and IGFBP-3 serum levels reflect endogenous GH secretion; GH also has direct effects independent of IGF-I, but systemic IGF-I is the main actor in the ossification process.
Yang et al., "Erratum to: Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting," Journal of Experimental & Clinical Cancer Research, vol.
Venous blood samples were drawn and centrifuged at 5000 rpm for 5 minutes for IGF-1 and IGFBP-3 measurements in the study group.
The serum ALP activity and concentrations of estradiol, osteocalcin, insulin-like growth factor 1 (IGF-1), IGF binding protein 3 (IGFBP-3), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were analyzed by using the appropriate enzymatic colorimetric kits in accordance with the manufacturer's instructions.
Results: The studies used biochemical markers such as GDF-15, ST-2, NT-proBNP, IL-6, IGF-1, IGFBP-3, levels of salivary testosterone and levels of salivary cortisol, physical data such as anthropometric measures and agility trials and specific questionnaires on overtraining that evaluated subjectives changes such as fatigue, lack of energy and self-regulation.
Aortic intima-media thickness, serum IGF-I, IGFBP-3, and leptin levels in intrauterine growth-restricted newborns of healthy mothers.
Circulating salmon 41-kDa insulin-like growth factor binding protein (IGFBP) is not IGFBP-3 but an IGFBP-2 subtype.
Wallace et al., (1999) who examined the effects of long-term exercises on somatotrop line in more detailed way found that while total blood GH, GHBP, IGF-1, IGFBP-3 levels were increasing, no change was seen in free IGF-1 concentrations, IGFBP-1 levels varied individually and particularly all parameters increased after the exercises.
The aim of the present study was to measure the concentration of IGF-I, expression of IGFBP-1 and IGFBP-3, and to evaluate gelatinolytic activity in both articular exudates and serum of patients with Lyme arthritis (studied group) and compared with those of patients with post-traumatic damage (control group).
Genetic Analysis of IGFBP-3 Gene and Its Association with Economic Traits in Goats.