IGFBP1

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IGFBP1

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP1 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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Tissue expression patterns of IGF-1 and IGFBP-1 genes
The expression patterns of IGF-1 and IGFBP-1 genes in the different tissues were investigated using semiquantitative reverse transcription-polymerase chain reaction (RT-PCR) on cDNAs obtained from the different tissues, and the [beta]-actin gene was chosen as the positive control.
Molecular characterization and expression analysis of insulin-like growth factor-1 and insulin-like growth factor binding protein-1 genes in Qinghai-Tibet plateau Bos grunniens and lowland Bos taurus
Overall, 26% of the ph IGFBP-1 test results were positive (had a value of at least 10 mcg/L), and 8% of the fetal fibronectin test results were positive (had a value of at least 50 ng/mL).
The ph IGFBP-1 test and the fetal fibronectin test had similarly good negative predictive values for preterm delivery (0.
New test eyed for ruling out preterm delivery
1c], fructosamine, and insulin were removed from consideration, 6 markers were selected: PAI-1, tumor necrosis factor receptor superfamily member 1A (TNFRSF1A), chemokine ligand 2, IL-2 receptor, IGFBP-1, and ACE.
However, 62% of the variance in insulin sensitivity could be accounted for by the markers IGFBP-1, leptin, PAI-1, GPT, and triglycerides in models where glycemic markers and insulin were excluded.
Biomarkers in fasting serum to estimate glucose tolerance, insulin sensitivity, and insulin secretion
Effects of betaine on the identification of IGFBPs and concentration of IGFBP-1 and-3
Among these IGFBPs bands, significant concentration variation of IGFBP-1 and 2 was found (Figure 3D).
Effects of dietary betaine on the secretion of insulin-like growth factor-I and insulin-like growth factor binding protein-1 and -3 in laying hens
There is evidence that serum IGFBP-1 concentrations are higher in the elderly than in younger people (35).
Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1 and IGFBP-3.
Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications
A number of reports have shown that IGFBP-1 is capable of both inhibition as well as augmentation of the IGFs' actions [4,21-241.
Changes in the phosphorylation state of IGFBP-1 have also been reported to result in significant change in its immunoreactivity [27].
Immunoassay of insulin-like growth factor binding protein-1

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