IGFBP1

(redirected from IGFBP-1)
Also found in: Acronyms.

IGFBP1

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP1 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
Mentioned in ?
References in periodicals archive ?
The best-performing glucose tolerance model (fasting glucose, leptin, IGFBP-1, GPT, and Hb[A.sub.1c]) was able to discriminate between individuals based on glucose tolerance status.
The prepared sample blots were initially incubated overnight with antibodies against IGPBP-3 and IGFBP-1 at 4[degrees]C, and treated with goat or rat antirabbit horseradish peroxidase.
[16] or to other factors (such as IGFBP-1 or SCF/SDF-1; either secreted or presented via cell-cell contacts), still has to be clarified.
Total, but not free, IGF-I and IGFBP-1 both increase after acute exercise (33).
There is evidence that serum IGFBP-1 concentrations are higher in the elderly than in younger people (35).
A number of reports have shown that IGFBP-1 is capable of both inhibition as well as augmentation of the IGFs' actions [4,21-241.
The first mechanism among these is that obesity leads to insulin resistance and hyperinsulinism, causing a reduction in insulin-binding protein 1 (IGFBP-1) levels.
Chapter 16 -- Global Preterm Birth Diagnostic Test Kits Market Analysis 2013-2018 & Opportunity Assessment 2019-2028, By Product Type Based on the product type, the Preterm birth diagnostic test kits market is segmented into Fetal Fibronectin Test Kits (fFN), Placental Alpha Micro-globulin-1 test kits (PAMG-1), Insulin like Growth Factor Binding Protein-1 test kits (IGFBP-1).
(1995) Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.
The cDNA probes for detecting apolipoprotein E (Apoe), fatty acid synthase (Fas), Gck, insulin-like growth factor-binding protein (Igfbp-1), and Pck1 genes have been published previously (23).
The majority of the commercially available tests is based on the estimation of insulin-like growth factor binding protein (IGFBP-1) in combination with other molecules, for example, alpha-fetoprotein (AFP) or interleukin 6 (IL-6) [15-18].