IGF2R


Also found in: Acronyms.

IGF2R

A gene on chromosome 6q26 that encodes a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). IGF2R plays a role in intracellular trafficking of lysosomal enzymes, activating transforming growth factor beta, IGF2 degradation and regulating T-cell coactivation by binding DPP4.
References in periodicals archive ?
The researchers observed inconsistent methylation and activity among the handful of imprinted genes that they tested, not including that for IGF2R, Jaenisch reported at the NAS meeting and in the July 6 SCIENCE.
15 HUMAN MOLECULAR GENETICS, the investigators report that the gene for IGF2R is not imprinted in primates, even though it is in rodents, pigs, sheep, and other animals that researchers have cloned.
But IGF2R is only one of many genes that contribute to intelligence, and there are other factors to take into account.
Allelic IGF2R repression does not correlate with expression of antisense RNA in human extraembryonic tissues.
Plomin emphasizes that the IGF2R variant associated with high IQs is not a "genius gene.
The IGF2R gene variant accounts for less than 2 percent of individual IQ disparities, or a difference of about 3 IQ points, according to Plomin.
Conservation of IGF2-H19 and IGF2R imprinting in sheep: effects of somatic cell nuclear transfer.
IGF2R and ERCC6 did not have sufficient comparative data for accurate prediction with these two programs but are also likely to be highly polymorphic.
Although the ASCL2 gene was not imprinted in pigs in our study, its effect on porcine carcass traits was not affected by its imprinted status, which is consistent with the results that IGF2 and IGF2R were not imprinted, but they also had important effects on body growth and carcass traits in chickens (Nolan et al.