IGF2R


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IGF2R

A gene on chromosome 6q26 that encodes a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). IGF2R plays a role in intracellular trafficking of lysosomal enzymes, activating transforming growth factor beta, IGF2 degradation and regulating T-cell coactivation by binding DPP4.
References in periodicals archive ?
The IGF2R gene may influence intelligence through interactions with other genes or with certain environments, making the type of analysis reported by Plomin's group difficult to interpret, Sternberg explains.
Plomin emphasizes that the IGF2R variant associated with high IQs is not a "genius gene.
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.
Since IGF2R normally plays a growth-suppressing role within the fetus, the scientists concluded that reduced activity of its gene could be responsible for large-offspring syndrome both in IVF and cloned embryos.
The researchers observed inconsistent methylation and activity among the handful of imprinted genes that they tested, not including that for IGF2R, Jaenisch reported at the NAS meeting and in the July 6 SCIENCE.
Primates and their close relatives have significantly diverged from all other mammals and animals in their expression of a certain gene involved in fetal growth and regulation, namely the IGF2R,"reported Killian.
Looking at chromosome 6, researcher Robert Plomin has found that children with high IQs--around 160--are twice as likely as the general population to have a slightly different version of the IGF2R gene.