IGF2


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IGF2

A gene on chromosome 11p15.5 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development. It is an imprinted gene and expressed only from the paternal allele.

Molecular pathology
Epigenetic changes at 11p15.5 are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome.
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In contrast, removal of endogenous SL by immunoneutralization could reduce IGF1 and IGF2 transcripts in a dose-dependent manner, suggesting that local production of SL is required to maintain basal level of IGFs gene transcription in tilapia hepatocytes.
Interestingly, both IGF1 and IGF2 are overexpressed in the stroma of fibroepithelial tumors.
Decreased DNA methylation at the IGF2 gene has been associated with an increased risk of developing certain cancers, including colorectal and ovarian cancers.
Genes relevantes sobre expresados en IB GEN ENTREZ GENE NAME FOLD CHANGE CASP 7 Caspase 7 2,02 ME1 Malic Enzyme 2,00 UBE2D4 Ubiquitin conjugating 1,57 enzyme ELOVL6 Fatty Acid Elongase 6 1,56 CASP4 Caspase 4 1,56 CTSL2 Cathepsin L2 1,44 Genes relevantes sobre expresados en DU x IB IGF2 Insuline-like ggrowth factor 2 -4,87 COL12A1 Collagen type XII alpha 1 -2,61 COL1A1 Collagen type I alpha 1 -2,17 UBA5 Ubiquitin-like modifier act.
22) This subgroup is of considerable interest due to the location of the IGF2 and H19 genes within this region, (16) indicating complex genetic/epigenetic associations of the imprinted 11p15 region in the pathogenesis of HB and other related tumours.
htm) found that children conceived during the famine had different DNA methylation patterns for a gene called IGF2, which is involved in human growth and development, compared to siblings that weren't exposed to the famine in the womb.
De otro lado, en los ultimos anos se han propuesto estudios de metilacion en CCR con multiples genes candidatos, entre ellos p16, MGMT, RASSF2AA, APC, RUNX3, MIN e IGF2 (56).
No fue sino hasta 2008 que Heijmans y otros autores reportaron los resultados de su investigacion de individuos holandeses expuestos a hambruna durante su desarrollo embrionario en la Segunda Guerra Mundial; estos investigadores encontraron cambios en la metilacion del gen IGF2 entre individuos expuestos y no expuestos y de esta manera lograron documentar experimentalmente la relacion entre hipotesis Barker y modificaciones epigeneticas (26).
Otro de los problemas cruciales sobre los que no se pudo profundizar, fue sobre el impacto que tiene el ejercicio fisico en los marcadores tumorales asociados al cancer de mama [ErbB-2, P53 FOSFOPROTEINA, proliferacion celular (Ki67), BRCA1, PCNA, receptores hormonales ER/PR, Bcl-2, DDB2 proteina, P27 PROTEINA, SKP2, IGF1, IGF2, IGFBP1-3, Estradiol] y de esta forma plantear las posibles vias y mecanismos biologicos de accion.
Durante el desarrollo el gen IGF2 y el gen H19 se expresan de manera conjunta y coordinada sugiriendo que los dos actuan bajo el control de los mismos elementos transcripcionales.