IGF2


Also found in: Acronyms.

IGF2

A gene on chromosome 11p15.5 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development. It is an imprinted gene and expressed only from the paternal allele.

Molecular pathology
Epigenetic changes at 11p15.5 are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome.
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Hypomethylation at the IGF2 DMR was linked to paternal obesity, however, the researchers did not find a significant association between paternal obesity and methylation patterns of H19 DMR.
We identified Cd-associated variations in the expression of six imprinted genes, DLX5, H19, NDN, IGF2-AS, IGF2, and THSD7A across studies and within both sexes, as well as sex-specific associations for CPA4, GRB10, and ILK.
IGF2BP2 was originally identified as an RBP capable of binding IGF2 mRNA [9], and later studies suggest that it also targets other transcripts, such as LAMB2 [10], LIMS2 [11], TRIM54 [11], UCP1 [12], and 12 other genes encoding mitochondrial components [12].
Then, UBC could modulate STAT5A and CEBPA in the WNT and the MAPK signaling pathways to inhibit DNA repair through the dysregulation of HIST2H2BE and to induce the accumulation of autoimmune defects through the dysregulation of IGF2, which might ultimately facilitate tumor growth.
We examined the effect of WIF-1 on differentiation of mouse pre-adipocytes 3T3 cells through the expression of Igf2, Wisp2, (C/EBP[delta]), and peroxisome proliferator-activated receptor [gamma] (PPAR[gamma]) which has been implicated as a suppressor in cell types including human breast, lung, and colon cancer.
Insulin-like growth factor 2 (IGF2) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes.
Beckwith-Wiedemann syndrome (BWS) is a genetic disorder at chromosome 11p15 that leads to increased activity of insulin-like growth factor-2 (IGF2) and reduced activity, with no active copy of the inhibitor of cell proliferation, CDKN1C, resulting in excessive growth and increased risk of tumour formation.
3-M syndrome: a growth disorder associated with IGF2 silencing.
A study carried out in Japan found evidence that points to paternal transition of obesity induced by a diet rich in fats, which can be passed through genomes and is related to the genes Peg3 and Igf2 (38).
H19, H19 was first described as an imprinted ncRNA transcript at the Igf2 locus.
Furthermore, the hsa-mir-15a was observed to correlate with the expression of IGF2. In the TCGA colon cancer study, the IGF2 was amplified and overexpressed.