IGF1R


Also found in: Acronyms.

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
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SemRep uses MetaMap [23] to map the text IGF1R and bladder cancer to the metathesaurus concepts "IGF1R gene" and "Carcinoma of bladder," which are associated with semantic types (or classes) "Gene or Genome" and "Neoplastic Process," respectively.
Polymorphisms of the IGF1R gene and their genetic effects on chicken early growth and carcass traits.
IGF1R is commonly activated in neoplastic growth and contributes to cell proliferation, cell survival, and resistance to cytotoxic agents.
A Phase 1 study of XL228, a potent IGF1R / AURORA / SRC inhibitor, in patients with solid tumors or hematologic malignancies" will be presented on Saturday, May 30, 2009, starting at 4:15 p.
CE decreased the expression of further genes encoding insulin-signaling pathway proteins including GSK3B, IGF1R, IGF2R, and PIK3R1.
Session Title: Experimental and Molecular Therapeutics 18 Abstract: 2902 Location: Hall B-F, Poster Section 36 Presentation Title: Generation of in vivo tumor models driven by Insulin-Like Growth Factor Receptor IGF1R and their use in the development of OSI-906, a selective IGF1R inhibitor Presenter: Lorena Lerner Date & Time: Wednesday, April 22, 2009 at 8:00 a.
Biomarkers such as insulin-like growth factor 1 receptor (IGF1R), phosphorylated AKT (pAKT), p-PRAS40 (T246), p-S6 (S235/236), mammalian target of rapamycin and IGF1R activity (in plasma), p53, p21, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL), pAKT, pRAS, phosphatase and tensin homolog, and B-Raf proto-oncogene serine/threonine-protein kinase (BRAF) are just a few examples of IHC markers that are requested for paraffin tissue biopsy specimens in the diagnosis of melanoma, sarcoma, and germ cell tumor in Cancer Therapy Evaluation Program trials.
Meanwhile, GH and IGF1R genes were mapped on SSC12, and many studies found that these two genes affected porcine growth and development (Wang et al.
Inhibitor of BCR-ABL, SRC, and IGF1R Shows Early Signs of Clinical Benefit in Patients With Resistant CML or Ph+ ALL
14,15) Finally, a third mechanism of acquired resistance to EGFR tyrosine kinase inhibitors elucidated in A431 cell lines is the activation of the IGF1R pathway via IRS-1.
Encouraging data on several of the compounds, including XL184 (MET, RET, VEGFR2), XL281 (RAF), and XL228 (BCR-ABL, IGF1R, SRC), were presented at the EORTC-NCI-AACR meeting this week, and there will be additional data presented on XL228 at the American Society of Hematology (ASH) meeting in December.
Inhibitor of IGF1R and SRC Shows Early Signs of Clinical Benefit