IGF1R


Also found in: Acronyms.

IGF1R

A gene on chromosome 15q26.3 that encodes a tyrosine kinase receptor with a high binding affinity for insulin-like growth factor, which plays a key role in transformation events in cell growth and survival.

Molecular pathology
IGF1R is highly overexpressed in cancer where it has anti-apoptotic activity, enhancing malignant cell survival.
Mentioned in ?
References in periodicals archive ?
Zaucke, "Insulin-like growth factor 1 receptor (IGF1R) signaling regulates osterix expression and cartilage matrix mineralization during endochondral ossification," Bone, vol.
The gene coding the IGF1 receptor (IGF1R), located on the long arm of chromosome 15, is involved in somatic development and glucose metabolism.
Modulation of reactive oxygen species (ROS) levels, inhibition of topoisomerases I and II, reduction of NF-[kappa]B and AP-1 activity, stabilization of p53, and inhibition of PI3K, STAT3, insulin-like growth factor 1 receptor (IGF1R), and human epidermal growth factor receptor 2 (HER2) have also been described as the causes behind the cancer chemopreventive and chemotherapeutic potential of luteolin [179].
It is well known that insulin and IGF-1 can cross activate each other's receptors (insulin receptor (InsR) and IGF1R) and that there is also significant crosstalk downstream to these receptors via the insulin receptor substrate proteins (IRS; Figure 1).
Among neural-derived cells, integrated mRNA-miRNA functional analyses of mature neurons (MNs), neural progenitor cells (NPCs), and neuroblastoma cells (NBCs) revealed that several very highly expressed genes (e.g., Robo1, Nrp1, Epha3, Unc5c, Dcc, Pak3, and Limk4) and a few underexpressed miRNAs (e.g., miR-152, miR-146b, and miR-339-5p) in MNs are associated with one important cellular process-axon guidance; some very highly expressed mitogenic pathway genes (e.g., Map2k1, Igf1r, Rara, and Runx1) and underexpressed miRNAs (e.g., miR-370, miR-9, and miR-672) in NBCs are associated with cancer pathways [23].
Original text: "The IGF1R is up-regulated in bladder cancer compared with non-malignant bladder, and might contribute to a propensity for invasion." [22]
Overexpression of growth factor receptors including the epidermal growth factor receptor (EGFR), the human epidermal receptor-2 (HER2) and the insulin-like growth factor-1 receptor (IGF1R) have all been suggested to play a central role in mediating an endocrine-resistant state [18-22].
This study analysed KRAS, BRAF, PI3KCA, MET, and IGF1R in 85 mCRC treated with cetuximab-based therapy in whom EGFR status was known.
The main goal of the current study was to investigate and follow the expression of both FSHR and IGF1R gene in different stages of COC development in the bovine without extracting RNA by using small number of cells as source of germ donor cells and extract these two genes from blood as a source of somatic cells to make a confirmation and comparison the results of gene expression in oocytes.
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (IGF1r).
Among these genes were phosphoserine phosphatase (PSPH), which was most unregulated; Ras-related associated with diabetes (RRAD); and two genes associated with insulin-like growth factor, insulin-like growth factor 1 receptor (IGF1R) and a variant, IMP-2.