IGF1


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IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.
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References in periodicals archive ?
IGF1 has significant biological functions including increases the stimulating myogenesis, intake of glucose, prevents apoptosis, attend the activation of cell cycle genes, interrupts in the synthesis of DNA, protein, RNA, and in cell proliferation, enhance the synthesis of lipids and stimulating the production of progesterone in granular cells (Etherton, 2004).
In addition, researchers will test if more translatable delivery of recombinant osteopontin and IGF1 proteins using multifunctional fibers can achieve similar restoration after SCI.
Individual increases in mean HR24h were associated with individual decreases in IGF1 (r = -0.46, p < 0.05, N = 25) from PRE-MID.
Mouse anti-human monoclonal antibodies against MDM2, IGF1, STAT1, and RAC1 were purchased from DAKO.
IGF1: insulin like growth factor 1, FSH: follicle-stimulating hormone, LH: luteinizing hormone, hCG: human chorionic gonadotropin.
Nos protocolos de hipertrofia, o estresse metabolico pode ser fator fundamental nos ganhos musculares, justamente por induzir o aumento das concentracoes de GH e IGF1, que sao importantes hormonios anabolicos.
Existen otros factores de crecimiento producidos por las celulas sustentaculares involucrados en interacciones paracrinas con las celulas intersticiales, tales como factor de crecimiento simil de insulina 1 (IGF1), factor de crecimiento fibroblastico (FGF) y factor de crecimiento transformante alfa (TGFA), los que aumentan, mientras que el factor de crecimiento transformante beta (TGFB) disminuye (Griffeth et al., 2013; Jiang et al., 2013; Young et al., 2015).
With the popularity of genetic research techniques, polymorphism of IGF1, MTNR1B, ESR1, CALM1, PAX1 , and WNT3A has been reported to be associated with idiopathic scoliosis.
MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1 R/mTOR signalling pathways.
Two growth factors IGF1 and TGF have been reported to be secreted products found in cultured human breast cancer cells.
Alves CX, Vale SH, Dantas MM, Maia AA, Franca MC, Marchini JS, Leite LD, Brandao-Neto J: Positive effects of zinc supplementation on growth, GH, IGF1, and IGFBP3 in eutrophic children.