IGFBP3

(redirected from IGF-binding protein 3)

IGFBP3

A gene on chromosome 7p13-p12 that encodes a member of the insulin-like growth factor binding protein (IGFBP) family that binds insulin-like growth factors I and II and circulates in the plasma. IGFBP3 binding prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
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The 18% who did not undergo stimulation testing had MPHD (hypothyroidism, adrenal insufficiency, and/or diabetes insipidus) and low IGF-I and IGF-binding protein 3 concentrations based on age, sex, and reference range.
Turgut, "Increased plasma levels of growth hormone, insulin-like growth factor (IGF)-I and IGF-binding protein 3 in pregnant rats with exercise," The Tohoku Journal of Experimental Medicine, vol.
Recently we reported on the high proteolytic activity of MMP9 in juvenile idiopathic arthritis patients with low amount of IGF-binding protein 3 (IGF-BP3), possibly by impairing the reparation processes stimulated by Insulin-like Growth Factor-I (IGF-I) [10].
Plasma insulin-like growth factor-I and serum IGF-binding protein 3 can be associated with the progression of breast cancer, and predict the risk of recurrence and the probability of survival in African-American and Hispanic women.
Are plasma insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) useful markers of prostate cancer?
Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3).
Steroid receptor coactivator 3 maintains circulating insulin-like growth factor 1 (IGF-1) by controlling IGF-binding protein 3 expression.
Gene expression of IGF-1, IGF-1 receptor (IGF-1R) and IGF-binding protein 3 (IGF-BP3) were quantified by real-time RT-PCR.
Levels of IGF-binding protein 3 (IGF-BP3), the chief IGF-l-specific binding protein, are also high relative to the low GH concentrations in these patients.
WASHINGTON -- Pretreatment plasma levels of insulin-like growth factor, IGF-binding protein 3, and vascular endothelial growth factor were highly predictive of disease outcomes in a study of patients with advanced non-small cell lung cancer, Ji-Youn Han, Ph.D., reported at the annual meeting of the American Association for Cancer Research.
Ranke, "Reference ranges for two automated chemiluminescent assays for serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3)," Clinical Chemistry and Laboratory Medicine, vol.