The ACAAinsertion/deletion polymorphism at the 3' UTR of the IGF-II receptor
gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
The IGF-II receptor
(IGF-IIR), which is homologous to the cation-independent mannose-6-phosphate receptor, has a high affinity for IGF-II .
However, in chickens, the IGF-II receptor
(cation-independent mannose-6-phosphate receptor) is present, but it does not bind IGF-II, indicating that the effects of IGF-II are mediated via the IGF-I receptor (Yang et al., 1991; Zhou et al., 1995).
(18) It has been suggested that abnormalities of IGF-II gene or IGF-II receptor
gene lead to up-regulation of IGF-II resulting in overgrowth of the placental tissue.
Both IGFs can bind to the IGF-I receptor with similar affinity, whereas the IGF-II receptor
preferentially binds IGF-II (Van der Ven et al.
Fish Insulin, IGF-I and IGF-II Receptors
: A Phylogenetic Approach1.