IGF2R

(redirected from IGF-II receptor)

IGF2R

A gene on chromosome 6q26 that encodes a receptor for both insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). IGF2R plays a role in intracellular trafficking of lysosomal enzymes, activating transforming growth factor beta, IGF2 degradation and regulating T-cell coactivation by binding DPP4.
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References in periodicals archive ?
The ACAAinsertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
The IGF-II receptor (IGF-IIR), which is homologous to the cation-independent mannose-6-phosphate receptor, has a high affinity for IGF-II [65].
However, in chickens, the IGF-II receptor (cation-independent mannose-6-phosphate receptor) is present, but it does not bind IGF-II, indicating that the effects of IGF-II are mediated via the IGF-I receptor (Yang et al., 1991; Zhou et al., 1995).
(18) It has been suggested that abnormalities of IGF-II gene or IGF-II receptor gene lead to up-regulation of IGF-II resulting in overgrowth of the placental tissue.
Both IGFs can bind to the IGF-I receptor with similar affinity, whereas the IGF-II receptor preferentially binds IGF-II (Van der Ven et al.