Cesarone et al., "Short stature associated with high circulating insulin-like growth factor (IGF)-binding protein-1 and low circulating IGF-II
: effect of growth hormone therapy," Journal of Clinical Endocrinology and Metabolism, vol.
The ACAAinsertion/deletion polymorphism at the 3' UTR of the IGF-II
receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
Moreover, in NIH3T3 fibroblasts, activation of IRA by pp120 undergoes faster internalization and recycling than IRB [42, 43] and is differentially regulated by IGF-II
and insulin .
Additionally, in a subset of 137 subjects, hormones (ALP, ALT, AST, SHBG, CRP, IGF-I, IGF-II
, 17[beta]-estradiol, and progesterone) and blood chemistries were included.
Then, either adherent cells (macrophages) or Leishmania amastigotes or promastigotes were preincubated for 5 minutes with 50 ng/mL recombinant human IGF-I or IGF-II
(R & D Systems, Minneapolis, MN, USA) and then washed out.
A family of IGF-II
mRNA binding proteins (IMP) involved in RNA trafficking.
"It was known in mammalian species that IGF-II
played a primary role in fetal development.
The receptor can also bind molecules that are not marked by M6P such as IGF-II
, retinoic acid, urokinase-type plasminogen activator receptor, and plasminogen.
Varios factores de crecimiento tienen un papel fundamental en la proliferacion y diferenciacion celular del condilo mandibular, como la hormona del crecimiento (GH), los factores de crecimiento insulinoide tipo I y tipo II (IGF-I e IGF-II
), el factor de crecimiento fibroblastico (FGF), el factor de crecimiento vascular endotelial (VEGF), el factor de crecimiento transformante-P y algunos factores de transcripcion, entre otros (27-29).
Luteolin decreases IGF-II
production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.
The activities of the growth factors IGF-I and IGF-II
are modulated by a family of IGF-binding proteins (IGFBPs).