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A gene on chromosome 11p15.5 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development. It is an imprinted gene and expressed only from the paternal allele.

Molecular pathology
Epigenetic changes at 11p15.5 are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome.
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Insulin-like growth factor II A protein homologue of IGF-I that may be produced by tumors and cause reactive hypoglycemia ↑ in Acromegaly, hepatoma, leiomyosarcoma, mesothelioma, Wilms' tumor ↓ in hGH deficiency, infants; IGF-II receptor is similar, if not identical to the mannose-6-phosphate receptor
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Cesarone et al., "Short stature associated with high circulating insulin-like growth factor (IGF)-binding protein-1 and low circulating IGF-II: effect of growth hormone therapy," Journal of Clinical Endocrinology and Metabolism, vol.
The ACAAinsertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance.
Moreover, in NIH3T3 fibroblasts, activation of IRA by pp120 undergoes faster internalization and recycling than IRB [42, 43] and is differentially regulated by IGF-II and insulin [44].
Additionally, in a subset of 137 subjects, hormones (ALP, ALT, AST, SHBG, CRP, IGF-I, IGF-II, 17[beta]-estradiol, and progesterone) and blood chemistries were included.
Then, either adherent cells (macrophages) or Leishmania amastigotes or promastigotes were preincubated for 5 minutes with 50 ng/mL recombinant human IGF-I or IGF-II (R & D Systems, Minneapolis, MN, USA) and then washed out.
A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.
"It was known in mammalian species that IGF-II played a primary role in fetal development.
The receptor can also bind molecules that are not marked by M6P such as IGF-II, retinoic acid, urokinase-type plasminogen activator receptor, and plasminogen.
Varios factores de crecimiento tienen un papel fundamental en la proliferacion y diferenciacion celular del condilo mandibular, como la hormona del crecimiento (GH), los factores de crecimiento insulinoide tipo I y tipo II (IGF-I e IGF-II), el factor de crecimiento fibroblastico (FGF), el factor de crecimiento vascular endotelial (VEGF), el factor de crecimiento transformante-P y algunos factores de transcripcion, entre otros (27-29).
Luteolin decreases IGF-II production and downregulates insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells.