Also found in: Acronyms.


A gene on chromosome 11p15.5 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development. It is an imprinted gene and expressed only from the paternal allele.

Molecular pathology
Epigenetic changes at 11p15.5 are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma and Silver-Russell syndrome.


Insulin-like growth factor II A protein homologue of IGF-I that may be produced by tumors and cause reactive hypoglycemia ↑ in Acromegaly, hepatoma, leiomyosarcoma, mesothelioma, Wilms' tumor ↓ in hGH deficiency, infants; IGF-II receptor is similar, if not identical to the mannose-6-phosphate receptor
References in periodicals archive ?
Colectivamente, estos resultados indican que en bovinos las celulas de la granulosa y una menor extension de las celulas tecales pueden contribuir con una porcion del IGF-1 y del IGF-II intrafolicular (Lenz et al.
Metabolic and mitogenic effects of IGF-II in rainbow trout (Oncorhynchus mykiss) myocytes in culture and the role of IGF-II in the PI3K/Akt and MAPK signalling pathways.
La mayoria de los tumores extrapancreaticos que producen hipoglucemia lo hacen por la secrecion excesiva del IGF-II de alto peso molecular que son liberados a la circulacion.
Follicular dominance in cattle is associated with divergent patterns of ovarian gene expression for insulin-like growth factor (IGF)-I, IGF-II, and IGF binding protein-2 in dominant and subordinate follicles".
Dentro de ellos estan los ARNm de TGF-[alfa], TGF-[beta]1, PDGF-[alfa], IGF-I, IGF-II, TGF-[beta]2, TGF-[beta]3, IL-3 e IL-6, ademas citoquinas como el factor inhibidor de la leucemia (LIF).
Co-expression of messenger ribonucleic acids encoding IGFI, IGF-II, type I and II IGF receptors and IGF-binding proteins (IGBP-1 to -6) during follicular development in the ovary of seasonally anoestrous ewes.
Palabras clave: GH, IGF-I, IGF-II, linfocitos, enfermedad trofoblastica gestacional.
Evidence exists for dissimilar roles of the two IGFs, in that IGF-II appears to be primarily responsible for the terminal differentiation of skeletal muscle cells and the down-regulation of IGF-I receptor gene expression, whereas IGF-I is responsible for myogenesis (Rosenthal et al.
Colon cancer cells have elevated levels of IGF-II compared to normal colon tissues.