IGF-I


Also found in: Acronyms.

IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.

IGF-I

Insulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarism
References in periodicals archive ?
Se sabe que IGF-I e IGF-II incrementan la proliferacion y supervivencia de fibroblastos placentales y que pueden rescatar estas celulas de la apoptosis.
IGF-I maintains NSC numbers by promoting cell division (via the IGF-I receptor), whereas IGF-II drives the expression of proteins essential for NSC self-renewal and 'sternness' (via the insulin receptor).
Conclusion: Baseline IGF-I levels may be used to predict response to levosimendan treatment in patients hospitalized for decompensated HE (Anadolu Kardiyol Derg 2011; 11.
Another condition with serum low IGF-I levels is Laron syndrome, the most common type of GH resistance.
We began studying the role of IGF-I in Leishmania infection based on the observation that IGF-I is produced by different cell types, including macrophages, and is present in the skin, which is the tissue where the parasite initiates infection [12].
Patients were included if they had GHD defined by peak GH level <10 ng/mL on both arginine, clonidine, and glucagon stimulation testing or multiple pituitary hormone deficiencies (MPHD) with low GH or IGF-I concentrations based on age, sex, and reference range documented GH treatment during the study period, and measurements of IGF-I and IGF-Iz during the study period.
Measurements of GH and IGF-I are used as complementary markers in both the diagnosis and long-term monitoring of treatment of acromegaly (4, 5).
Betka, "Serum levels of IGF-I, HGF, TGFbeta1, bFGF and VEGF in thyroid gland tumors," Physiological Research, vol.
Imanieh, "Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells," Cell Biology International, vol.
Zapf, "Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo," Endocrinology, vol.
Genomic DNA was extracted from growing feather pulp using standard Phenol Chloroform Isoamylalcohol (PCI) method and the polymorphism of IGF-I gene was detected by PCR-RFLP-PstI.