IGF-I


Also found in: Acronyms.

IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.

IGF-I

Insulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarism

IGF-I

References in periodicals archive ?
In adults, sex and ethnicity are minor contributors to variation in IGF-I concentrations.
Professor David Gunnell and his colleagues measured levels of Insulin Growth Factor IGF-I in the blood of the children, who also took an intelligence test at the age of eight.
A new study in diabetic rats suggests that this second type of diabetes-induced nerve damage can be reversed with doses of an insulinlike growth factor called IGF-I.
The scientists' next step will be to cross IGF-I pigs with market-line hogs to see if increased levels of hormone enhance muscle development in already-lean, heavy-muscled crossbred market hogs.
Primer sequences for amplification of the regions of IGF-I gene (target gene) and GAPDH (reference gene) sequences were designed using Beacon designer software by Chemoscience Company, Malaysia and synthesized by 1st BASE, Malaysia (Table 1).
All pigs were bled via venipuncture for IGF-I and IGF-II analyses at 21 and 28 days of age.
However, data from studies evaluating IGF-I response to exercise are controversial.
Insulin-like growth factors (IGF-I, free IGF-I, and IGF-II) and insulin-like growth factor binding proteins (IGFBP-2, IGFBP-3, IGFBP-6, and ALS) in blood circulation.
There are ample data that we can negate these risks if we are able to normalize growth hormone and IGF-I [insulin growth factor-I] levels.
Miller observed that IGF-I and one of the other growth factors, epidermal growth factor (EGF), shortened the animals' recovery period.