IGF-I


Also found in: Acronyms.

IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.

IGF-I

Insulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarism

IGF-I

References in periodicals archive ?
16) described a decrease of free IGF-I within the first week after surgery in patients who were later shown to be in remission.
Therefore, the characterisation of IGF-I, IGFBPs and IGF-BP-cleaving proteases in synovial fluid is important for understanding the modulation of synovial fluid metabolism in inflammatory processes affecting the knee joints.
Recent studies have shown that elevated levels of serum IGF-I correlate with overproduction of sebum and acne [17] as a result of IGF-I and insulin induced lipogenesis of sebaceous glands, probably by induction of sterol response element-binding protein-1 (SREBP-1) [12].
Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report.
The stages o fthe first phaseo f this study consisted of goat semen collection, seminal plasma p reparation, seminal plasma protein purification, Native Polyacrylamide Gel Electriforesis (Native -PAGE) of seminal plasma, electro elution for isolation of protein IGF-I Complex.
There was no difference in the mean ([+ or -]SD) serum estradio1-171, progesterone and IGF-I concentrations between camels with different ovulatory-sized follicles (p>0.
The role of IGF-I and -II in maintaining NSC numbers and function might help to explain the cognitive impairments associated with aging, as the abundance of both proteins declines with age.
Prevention of cardiomyocyte loss through suppression of cell death pathways has been proposed as a treatment strategy for the prevention of progression of HE On the other hand, IGF-I has been shown to decrease cardiomyocyte apoptosis in animal models (11-13).
El IGF-I cumple un papel importante en la reproduccion de la hembra bovina, tanto directamente cumpliendo funciones sobre el sistema reproductivo como indirectamente siendo indicador de una aceptable condicion corporal y aptitud reproductiva (Velazquez et al.
The results of both in vitro and in vivo studies suggest that elevated levels of endogenous insulin-like growth factor-I (IGF-I), observed during a 2-week endurance training of laboratory animals, increases myocardial expression of IGF-I (Scheinowitz et al.