IGF-I

Also found in: Acronyms.

IGF1

A gene on chromosome 12q23.2 that encodes a protein, similar to insulin in structure and function, which belongs to a family of proteins involved in mediating growth and development.

Molecular pathology
IGF1 mutations are a cause of insulin-like growth factor I deficiency.

IGF-I

Insulin-like growth factor I, somatomedin-C A polypeptide hormone structurally similar to proinsulin, synthesized in the liver and fibroblasts, giving fibroblasts a paracrine function; serum levels correlate with development of 2º sex characteristics in puberty ↑ in Acromegaly, gigantism ↓ in starvation, anorexia nervosa, African pygmies, ↓ somatomedins, Laron dwarfism, kwashiorkor, liver disease in children, GH deficiency, hypopituitarism

References in periodicals archive ?

IGF-I maintains NSC numbers by promoting cell division (via the IGF-I receptor), whereas IGF-II drives the expression of proteins essential for NSC self-renewal and 'sternness' (via the insulin receptor).

How growth factors cooperate to maintain neural stem cells

Conclusion: Baseline IGF-I levels may be used to predict response to levosimendan treatment in patients hospitalized for decompensated HE (Anadolu Kardiyol Derg 2011; 11.

Value of IGF-I levels in the evaluation of response to treatment with levosimendan in patients with severe heart failure/Ciddi kalp yetersizligi olan hastalarda levosimendan tedavi yanitini degerlendirmede IGF-I duzeyinin degeri

Assessing skeletal maturity by using blood spot insulin-like growth factor I (IGF-I) testing.

Serum Insulin like Growth Factor-1--A Skeletal Maturity Indicator for the Assessment of Orthopedic Treatment Timing of Skeletal Class II Malocclusion

Another condition with serum low IGF-I levels is Laron syndrome, the most common type of GH resistance.

Same Phenotype in Children with Growth Hormone Deficiency and Resistance

We began studying the role of IGF-I in Leishmania infection based on the observation that IGF-I is produced by different cell types, including macrophages, and is present in the skin, which is the tissue where the parasite initiates infection [12].

Insulin-Like Growth Factor-I as an Effector Element of the Cytokine IL-4 in the Development of a Leishmania major Infection

Patients were included if they had GHD defined by peak GH level <10 ng/mL on both arginine, clonidine, and glucagon stimulation testing or multiple pituitary hormone deficiencies (MPHD) with low GH or IGF-I concentrations based on age, sex, and reference range documented GH treatment during the study period, and measurements of IGF-I and IGF-Iz during the study period.

Treatment of Pre-pubertal Patients with Growth Hormone Deficiency: Patterns in Growth Hormone Dosage and Insulin-like Growth Factor-I Z-scores

Measurements of GH and IGF-I are used as complementary markers in both the diagnosis and long-term monitoring of treatment of acromegaly (4, 5).

Decrease of Serum IGF-I following Transsphenoidal Pituitary Surgery for Acromegaly

Betka, "Serum levels of IGF-I, HGF, TGFbeta1, bFGF and VEGF in thyroid gland tumors," Physiological Research, vol.

The Clinical Values of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Levels in Blood and Thyroid Nodules

Imanieh, "Insulin-like growth factor 1 (IGF-I) improves hepatic differentiation of human bone marrow-derived mesenchymal stem cells," Cell Biology International, vol.

Regulation of Osteogenic Differentiation of Placental-Derived Mesenchymal Stem Cells by Insulin-Like Growth Factors and Low Oxygen Tension

Zapf, "Effect of growth hormone and insulin-like growth factor I (IGF-I) on the expression of IGF-I messenger ribonucleic acid and peptide in rat tibial growth plate and articular chondrocytes in vivo," Endocrinology, vol.

Astragalus Extract Mixture HT042 Increases Longitudinal Bone Growth Rate by Upregulating Circulatory IGF-1 in Rats

Genomic DNA was extracted from growing feather pulp using standard Phenol Chloroform Isoamylalcohol (PCI) method and the polymorphism of IGF-I gene was detected by PCR-RFLP-PstI.

Short Communication - POLYMORPHISM OF INSULIN-LIKE GROWTH FACTOR-1 GENE AND ITS ASSOCIATION WITH GROWTH RATE IN DESI CHICKEN OF PAKISTAN