IFNG


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IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.
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The PPI network consists of 27 upregulated proteins including LCK, CD3G, CD3E, CD3D, IFNG, VAV1, TNF, B2M, CXCR3, CCR5, CCL5, CXCL9, CXCL10, CXCR4, GNG2, IL1B, IL12B, IL2RB, IL2RA, IL2RG, STAT1, CD8A, CD86, PTPRC, PIK2CG, CD44, and HLADPA1 and 1 downregulated protein EGF.
Ten genes (TLR2, NFKB 1, TNF, IFNG, IL2, CXCR3, PRKCB1, RPS6KB2, STK17B and EEF1) were found significantly upregulated in PBMC's of indigenous Tharparkar cattle as compared to Vrindavani (Table 2).
The rest of the regulatory nodes in the network are represented by cytokines (TFN, TGFB1, and IFNG).
PLA2G2E, IFNG, IL26 and IL22 are known to play a role in inflammation and the immune response.
La hCG (hormona Gonadotrofina Corionica Humana) junto con la citoquina denominada como Interleukina-4 (IL4), estimulan la produccion de LIF y su produccion es inhibida por IFNG (Interferon Gamma).
In preclinical studies, APVO436 induced lower levels of several key T-cell cytokines, including IFNg, IL-2, IL-6, and TNFa.
IFN-[gamma] production may be influenced by the presence of polymorphisms in the gene that encodes this cytokine, of which the most studied is the IFNG + 874 A/T polymorphism.
Higher serum concentrations of nine analytes [CCL-1, 7, 15, 17, and 19; CXCL-2 and 9, interferon gamma (IFNG), and macrophage migration inhibitory factor (MIF)] were detected in the TS-CONTROL group compared to the TS-COPD group.
In terms of cytokines, IL1B was expressed by all of the E-MpMs, and the Th1 antitumour cytokine IFNG was clearly expressed in three, but negative in E-MpM samples yet displaying a strong CD3 cell infiltration, as assessed by IHC analysis (samples no.
Polychlorinated biphenyls (PCBs) congener 126 and congener 153 modify the following inflammation related genes: AHR, CXCL2, HMOX1, IFNG, IL6, PTGS2, SOD2, and TNF; AHR, CXCL8, HMOX1, IL1B, IL6, MMP9, NOS2, NOS3, PARP1, PTGS2, and TNF; and AHR, IFNG, IL1B, PARP1, PTGS2, and TNF.
RT-qPCR assays were performed to detect the expression levels of Tbet (Mm_00450960_m1), Tnf (Mm_00443258_m1), Ifng (Mm_00801778_m1), Col1a1 (Mm_0801666_g1) Il1b (Mm_0043228_m1), Il6 (Mm_00446190_m1), and Ptprc (Mm_01293577_m1).
Transcripts of the markers of inflammation and endoplasmic reticulum and carbonyl stress Ccl2, Tnfa, Cxcr3, Adgre1, Ddit3, and Ager, but not Ifng, increased significantly in WT-HFD mice, but not in Pr[2x.sub.7.sup.-/-]-HFD animals (Table 2).