IL28B

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IL28B

A gene on chromosome 19q13.13 that encodes interleukin-28B, an immunomodulatory cytokine which upregulates MHC class-I antigen expression. It has potent antiviral activity and has antitumour activity. IL28B is a ligand for the heterodimeric class-II cytokine receptor composed of IL10RB and IL28RA, which is thought to act via the JAK-STAT pathway. Difference between the two isoforms of IL28 (IL28A and IL28B) remains unclear.
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In 2009, single nucleotide polymorphisms (SNP) of the IFNL3 gene (rs12979860) were related to natural clearance of HCV.
7) Nonetheless, some patients still experience treatment failure due to on-treatment viral breakthrough or relapse after cessation of therapy, possibly attributed to unknown host and viral factors, such as IFNL3 gene polymorphism.
Those results prompted discussion on the relationship of polymorphisms near the IFNL3 gene and SVR to DAA-based regimens.
Thus, the objectives of the present study were to assess the prevalence of rs12979860-CC, rs12979860-CT, and rs12979860TT genotypes of the IFNL3 gene and its relationship with ancestry markers in a Brazilian population.
Our study evaluated the link between race and polymorphisms near the IFNL3 (formerly known as IL28B) gene among healthy voluntary blood donors using AIM as a surrogate for ancestry.
IFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6.
Clinical pharmacogenetics implementation consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-a-based regimens.
Objective: To describe the risk factors for infection, complications, treatment received and response in Puerto Ricans with HCV attending gastroenterology clinics at UPR-MSC, and the prevalence of single nucleotide polymorphisms (SNPs) in IFNL3 and IFNL4 in this population.
The SNP frequencies (n = 239) of IFNL3 locus rsl2979860 were 27% (C/C), 50% (C/T), and 23% (T/T), and for rs8099917 were 46% (T/T), 47% (T/G), and 7% (G/G).
Key words: Hepatitis C, IFNL3, IFNL4, Single Nucleotide Polymorphisms, Puerto Ricans, Hispanics
Objetivos: El proposito del estudio fue describir factores de riesgo, complicaciones, tratamiento, respuesta y prevalencia de polimorfismos de nucleotidos sencillos (PNS) en IFNL3 e IFNL4 en puertorriquenos con hepatitis C en las clinicas de Gastroenterologia- UPR.
IFNL3 CC genotype, a good human prognostic factor of treatment outcome, was also found in a percentage similar to other Brazilian study.