IFNG


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IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.
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06 Sample types and genes Blood ACTB IL1B CASP3 IFNG Mean Cq 16.
The allelic effects of the IFNG gene SNP on antibody response in both [F.
The IFNG SNP was highly significantly associated (p<0.
Additionally, 3 of the 7 remaining tests of association of IFNG polymorphism with BW at various ages in the two lines were p<0.
The allelic effects of IFNG polymorphisms on BW at 2, 6, and 12 wk of age are presented in Table 4.
2] population were determined and the major finding was the association of a novel IFNG promoter-region SNP with multiple traits of immune response and with BW in the [F.
There were three SNP detected previously in the IFNG promoter region in the same [F.
2] population demonstrated that a different IFNG promoter SNP than that characterized in the current study was associated with the level of circulating IFNG protein level after both primary and secondary immunization (Zhou et al.
2] population, the effect of a different IFNG SNP than that analyzed in the current study.
The effects of the IFNG SNP differed between the two [F.
This appears to be the case for IFNG and C-JUN in EDTA tubes (Fig.
Induction of IFNG, TNF, and ICAM over time was also observed, suggesting possible contact activation of cells in the EDTA collection tubes, which could lead to altered expression of genes involved in the proinflammatory process (11).