IFNG

(redirected from IFN-gamma)

IFNG

A gene on chromosome 12q14 that encodes a soluble cytokine belonging to the type-II interferon family that has antiviral, immunoregulatory and anti-tumour properties, and is a potent macrophage activator. It is produced by lymphocytes activated by specific antigens or mitogens.

Molecular pathology
Defects in IFNG is associated with increased susceptibility to aplastic anaemia in Caucasians.
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The paper, titled "Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-gamma and IL-12" appears in the December 18, 2018 issue of Immunity.
Since caloric restriction prevents chronic inflammation, the increased (P<0.05) serum levels of GM-CSF, IFN-gamma, and KC (HFD vs HFD-FR), represent an unexpected result.
A single nucleotide polymorphism in the first intron of the human IFN-gamma gene: Absolute correlation with a polymorphic CA microsatellite marker of high IFN-gamma production.
Brunham, "Genetically determined differences in IL-10 and IFN-gamma responses correlate with clearance of chlamydia trachomatis mouse pneumonitis infection," Journal of Immunology, vol.
This study compares miR-122 and lipoprotein lipase expression in the liver and PBMCs and investigates how these parameters are associated with lipid profile, with HCV load and IFN-gamma, revealing the reverse correlation between lipoprotein lipase and miR-122 expression in the liver of CHC patients.
Zheng, "Serum levels of IFN-gamma and IL-4 in children with Mycoplasmal pneumonia at the acute phase," Chinese Journal of Contemporary Pediatrics, vol.
Glimcher, "Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells," Science, vol.
In contrast to single-agent pembrolizumab therapy, responders to the combination regimen included patients with very low levels of CD8+ T-cell infiltrates or negative interferon-gamma (IFN-gamma) gene signatures in baseline tumor biopsies, suggesting that oncolytic virotherapy might make anti-programmed death-1 (PD-1) therapy more effective by altering the tumor microenvironment, the researchers concluded.
tuberculosis specific IFN-gamma and IL-2 ELISPOT assays in discriminating children with active or latent tuberculosis.
Tripathi, "Differential clinical symptoms among acute phase Indian patients revealed significant association with dengue viral load and serum IFN-gamma level," Journal of Clinical Virology, vol.
Decreasing IFN- [gamma] level after one week from initiation treatment agree with study done by Eisenhut, [19] who reported ability of IL-4 interferes with TH 1 cell development and reduces the production of IFN-gamma. Hardy et al., [20] show the capacity range of probiotic strains live cells to induce of cytokines drive Th1 differentiation (IL-12), also hence IFN-[gamma] production and Th2 differentiation (enhance IL-4 production).