IFITM3

IFITM3

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication.
 
Molecular pathology
IFITM3 mutations are linked to increased susceptibility to viral infections.
References in periodicals archive ?
The research team found that IFITM3 normally stops multiplication of the virus in human cells at an early step, preventing the infected cells from "implosive" cell death.
118 Recently, IFITM3 and IFITM1 were also shown to inhibit the replication of ZIKV.
Selon une etude menee par une equipe de chercheurs de l'universite du Massachusetts, notre corps serait capable de se defendre face au virus Zika, grace a une proteine appelee IFITM3.
In some cases, IFITM3 can also prevent Zika virus from killing our cells.
The predicted inhibition of the interferon-signaling pathway by KJ and APE was due to significant downregulation of six genes; IFI35, IFIT1, IFITM1, IFITM3, IRFl, PSMB8 encoding interferon-induced protein 35, interferon-induced protein with tetratricopeptide repeats 1, interferon induced transmembrane protein 1, interferon induced transmembrane protein 3, interferon regulatory factor 1, and proteasome subunit beta type 8, respectively.
Notably, the Hang group has recently discovered several fatty-acylated proteins which are directly involved in host resistance to pathogens, such as IFITM3 and the autophagy factor Irgm1 (unpublished).
A report published in the journal Clinical Infectious Diseases by Dr David Hui of the Chinese University of Hong Kong said H7N9 flu virus spreads easily and more among the Chinese because of the IFITM3 gene (interferon-induced transmembrane protein-3 gene).
When a virus tries to enter, the immune system gets stimulated by interferon, which produces almost 300 host proteins, including IFITM3.
In a previous study involving mostly people of European descent, scientists found that a few individuals carried a particular form of a gene known as IFITM3 and got hit especially hard by the flu.
Mice without IFITM3 had a "catastrophic" reaction to the virus, the Wellcome Trust Sanger Institute wrote in Nature.
Elledge y Abraham Brass, descubrio el funcionamiento de la familia de proteinas llamada transmembrana inducida por proteinas (IFITM1, IFITM2 e IFITM3, por sus siglas en ingles) que ya se conocia desde 1984.
Previous studies have shown that people who have a genetic variant, or allele, of the IFITM3 gene are more susceptible to the development of severe influenza.