IFITM3

IFITM3

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication.
 
Molecular pathology
IFITM3 mutations are linked to increased susceptibility to viral infections.
References in periodicals archive ?
The predicted inhibition of the interferon-signaling pathway by KJ and APE was due to significant downregulation of six genes; IFI35, IFIT1, IFITM1, IFITM3, IRFl, PSMB8 encoding interferon-induced protein 35, interferon-induced protein with tetratricopeptide repeats 1, interferon induced transmembrane protein 1, interferon induced transmembrane protein 3, interferon regulatory factor 1, and proteasome subunit beta type 8, respectively.
Notably, the Hang group has recently discovered several fatty-acylated proteins which are directly involved in host resistance to pathogens, such as IFITM3 and the autophagy factor Irgm1 (unpublished).
A report published in the journal Clinical Infectious Diseases by Dr David Hui of the Chinese University of Hong Kong said H7N9 flu virus spreads easily and more among the Chinese because of the IFITM3 gene (interferon-induced transmembrane protein-3 gene).
The IFITM3 gene is the one that increases influenza disease severity.
Higher than normal levels of cytokines, driven by a genetic variant of a protein called IFITM3, tells us that the severe disease is likely," she said.
We call this a Cytokine Storm and people with the defective genetic variant of the protein IFITM3 are more likely to succumb to severe influenza infection.
When a virus tries to enter, the immune system gets stimulated by interferon, which produces almost 300 host proteins, including IFITM3.
In a previous study involving mostly people of European descent, scientists found that a few individuals carried a particular form of a gene known as IFITM3 and got hit especially hard by the flu.
Mice without IFITM3 had a "catastrophic" reaction to the virus, the Wellcome Trust Sanger Institute wrote in Nature.
People who carry a particular variant of a gene called IFITM3 are significantly more likely to be hospitalised when they fall ill with influenza than those who carry other variants, a research led by the Wellcome Trust Sanger Institute found.
IFITM3 is an important protein that protects cells against virus infection and is thought to play a critical role in the immune system's response against such viruses as H1N1 pandemic influenza, commonly known as 'swine flu'.
Researchers from the Wellcome Trust Sanger Institute and the Roslin Institute at the University of Edinburgh have identified a gene, IFITM3, responsible for the body's response to flu and other viruses, the Independent reported.