IFITM2

IFITM2

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation in a p53-independent manner.
References in periodicals archive ?
(II) In schizophrenia, transcriptome analysis of brain tissue from autopsy of schizophrenic patients showed an increased expression of IFITM2, IFITM3, SERPINA3, and GBP1 was found.
In this study on glioma cells, the activation of numerous interferon-induced proteins (such as IFIT1, IFIT2, IFI27, IFITM1, IFITM2, and G1P2) lends support to this mechanism of pathogenicity.