IFITM2 | definition of IFITM2 by Medical dictionary
IFITM2 A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation in a p53-independent manner.
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References in periodicals archive
(II) In schizophrenia, transcriptome analysis of brain tissue from autopsy of schizophrenic patients showed an increased expression of IFITM2
, IFITM3, SERPINA3, and GBP1 was found.
In this study on glioma cells, the activation of numerous interferon-induced proteins (such as IFIT1, IFIT2, IFI27, IFITM1, IFITM2
, and G1P2) lends support to this mechanism of pathogenicity.