IFITM1

IFITM1

A gene on chromosome 11p15.5 that encodes an interferon-induced protein, which mediates innate cellular immunity against viral pathogens—e.g., influenza A H1N1, West Nile, and dengue viruses—by inhibiting the early steps of viral replication. IFITM1 downregulates IFN-gamma by inhibiting ERK activation, or by arresting p53-dependent cell growth in G1.
References in periodicals archive ?
118 Recently, IFITM3 and IFITM1 were also shown to inhibit the replication of ZIKV.
The predicted inhibition of the interferon-signaling pathway by KJ and APE was due to significant downregulation of six genes; IFI35, IFIT1, IFITM1, IFITM3, IRFl, PSMB8 encoding interferon-induced protein 35, interferon-induced protein with tetratricopeptide repeats 1, interferon induced transmembrane protein 1, interferon induced transmembrane protein 3, interferon regulatory factor 1, and proteasome subunit beta type 8, respectively.
In this study on glioma cells, the activation of numerous interferon-induced proteins (such as IFIT1, IFIT2, IFI27, IFITM1, IFITM2, and G1P2) lends support to this mechanism of pathogenicity.