IFIH1

IFIH1

A gene on chromosome 2q24.2 that encodes an RNA helicase which, through its ATP-dependent unwinding of RNA, may promote message degradation by specific RNases. It is thought to have roles in suppressing growth and involved in innate immune defence viruses.

Molecular pathology
Genetic variation in IFIH1 is associated with diabetes mellitus insulin-dependent type 19.
References in periodicals archive ?
When physicians conducted a genetic analysis, it revealed she had a mutation in the IFIH1 gene that led her body to produce dysfunctional MDA5 proteins, which are vital to the immune system.
In an effort to understand if the IFIH1 mutation affects other people, the researchers looked at more than 60,000 volunteers' DNA.
The analysis revealed that she had a mutation in the IFIH1 gene that caused her body to make dysfunctional MDA5 proteins in cells in her respiratory tract.
To explore whether other people experience poor health related to the IFIH1 gene, researchers analyzed a database of over 60,000 volunteers genomes.
The blood panel manufacturer could add an IFIH1 allele indicator to their test, and flag that one-in-a-thousand baby that will need special attention at flu season," he wrote.
Although an IFIH1 indicator test "probably will be a good investment given the burden of pneumonia on health care systems," she says, at this point it is unclear if or when such a test would be developed.
Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.
Besides these well-established non-HLA loci, a number of other associations with T1D have been reported for IL2RA/CD25 (52, 53), SUMO4 (small ubiquitinlike modifier 4) (54) and IFIH1 (55, 56).
The minor allele of rs1990760 in the IFIH1 gene was reported to be associated with T1D, with a risk ratio of 0.
Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes.
The final results found four rare SNPs in the IFIH1 gene with strong statistical evidence of association with the disease.
Eight had one of three rare variants in the IFIH1 gene that cause the gene's protein to be shorter than normal.