IRGM

(redirected from IFI1)

IRGM

A gene on chromosome 5q33.1 that encodes immunity-related GTPase family member M (interferon-inducible protein 1), a putative GTPase required for clearing acute protozoan and bacterial infections. IRGM is thought to play a role in the innate immune response by regulating autophagy; it may regulate proinflammatory cytokine production and prevent endotoxaemia upon infection, and it may play a role in macrophages adhesion and motility.

Molecular pathology
Defects in IRGM cause susceptibility to inflammatory bowel disease type 19.
References in periodicals archive ?
showed that the NFI (1980) belongs to the IFI1 class and the TLI (1973) belongs to the IFI2 class of indices.
Several other indices which involve model comparisons were used in three or fewer studies: NNFI (11%), PGFI (11%), IFI1 (7%), IFI2 (7%), RP ratio (4%), and RPFI (4%).
The RNFI, PFI, PGFI, IFI1, IFI2, RP, RPFI, and CFI, which had not been introduced at the time of the studies presented in the James and James review, have been used in studies since 1987.