ICAM5 | definition of ICAM5 by Medical dictionary
ICAM5 A gene on chromosome 19p13.3-p13.2 that encodes a protein of the intercellular adhesion molecule (ICAM) family of type-I transmembrane glycoproteins. ICAM5 is expressed on the surface of telencephalic neurones and displays 2 types of adhesion: homophilic binding between neurones and heterophilic binding between neurones and leukocytes. It may play a critical role in neuron-microglial cell interactions during normal development or be involved in neurodegenerative disease.
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References in periodicals archive
Whether the newer EV-D68 strains causing an outbreak of severe respiratory infections in 2008-2010 were evolved to use primarily [alpha]2,3-linked sialic acid or have switched to a sialic acid-independent mechanism of virus entry (14), such as ICAM5
(15), needs further investigation.
Genetic variation in ICAM5
has not been found to be associated with drug dependence in GWAS studies, and has not been a focus of other genetic approaches, although MMP9 has been associated with alcohol dependence , and was identified in the brains of cocaine abusers in a transcriptional study .
In other studies, experience dependent plasticity induced in animals by trimming their whiskers to cause sensory deprivation resulted in -20% to -30% lower levels for the SAMs Pcdh1, ICAM5
, Plexin-A1, and Lphn 3 in juvenile mice (a period where synaptogenesis peaks) .