ICAM2

ICAM2

A gene on chromosome 17q23-q25 that encodes an intercellular adhesion molecule, which, like all ICAMs, is a type-I transmembrane glycoprotein with multiple immunoglobulin-like C2-type domains, and which binds to leukocyte adhesion LFA-1 protein. ICAM2 is involved in lymphocyte recirculation and mediates adhesive interactions critical for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation and other cellular interactions of the immune response and surveillance.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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In OSCC (oral squamous cell carcinoma), miR125b regulates proliferation and radiosensitivity by targeting ICAM2 [25] and miR-17-5p regulates expression of p21 [26].
Production of transgenic pigs harboring multi human complement regulatory protein were produced by co-injection experiments and the genes were expressed in a non-segregating site of the host genome using the human elongation factor1 alpha (Monoret et al., 2004), chick beta-actin (Byrne et al., 1995), and ICAM2 (Cowan et al., 2003) promoter.
ICAM2 mediates transmigration independently and PECAM1 participates in diapedesis in a cytokine specific manner (35).