A gene on chromosome 19p13.3-p13.2 that encodes a cell surface glycoprotein expressed on endothelial cells and cells of the immune system. It binds to integrins CD11a/CD18 or CD11b/CD18, and serves as a cell receptor for rhinoviruses.
The association between well-water As and stroke was significantly modified by 11 SNPs in six genes (see Supplemental Material, Table S4), and ICAM1 rs281432 remained significant after FDR adjustment ([p.
For instance, there was evidence of a synergistic interaction between ICAM1 rs281432 and urinary As on CVD (p = 0.
We observed a significant interaction of well-water As with ICAM1 rs128432 and VCAM1 rs3176867 for CVD on both multiplicative and additive scales.
We observed significant interactions of well-water As with rs281432 in ICAM1 and rs3176867 in VCAM1 for CVD.
Among the GIH population (Gujarati Indians in Houston, Texas) in the Hapmap 3 SNP data set, ICAM1 rs28l432 was not found, and no proxy SNPs were identified for VCAM1 rs3176867 (SNAP; Johnson et al.
We estimated significant interactions of As exposure with ICAM1 rs281432 and VCAM1 rs3176867 on CVD.