The results suggested that four key pathways (metabolic pathways, TNF signaling pathway, rRNA processing, and cytoplasm), the key gene ICAM1
, three miRNAs (hsa-miR7-5p, hsa-miR-433-3p, and hsa-miR-133b), and six TFs (ZBTB7A, OVOL1, GATA3, TFDP1, SMAD1, and QSOX) might play important roles in PD development.
Next, the protein-protein interaction (PPI) network was evaluated and top degree hub genes were listed: ubiquitin A-52 residue ribosomal protein fusion product 1 (UBA52), ribosomal protein L38 (RPL38), integrin subunit alpha L (ITGAL), intercellular adhesion molecule 1 (ICAM1
), interleukin 7 receptor (IL7R), interleukin 7 (IL7), REL protooncogene, NF-KB subunit (REL) and NF-KB inhibitor alpha (NFKBIA), Vav guanine nucleotide exchange factor 1 (VAV1), and lymphocyte cytosolic protein 2 (LCP2).
* Downregulated ICAM1
, Vimentin, MMP9, Twist, VEGF, 1L-6 and IL-8.
They also stimulate the osteoklastogenesis and the expression of genes associated with inflammation as well as inducing the expression of ICAM1
in the bronchial epithelial cells .
Overexpression of human full length MARCH9 results in reduced expressions of MHC I, HLA-DM, -DQ, -DR and -DO, CD4, ALCAM, and ICAM1
at the cell surface, suggesting a possible role in immune regulation or signaling [6, 15, 31, 47].
, and VCAM-1 are important in pancreatic cancer, where they participate in the detachment of cells from the primary tumor and contribute to cancer spread , and their overexpression in pancreatic adenocarcinomas is associated with a stimulation in tumor growth, increased metastatic ability, and potentially shorter postoperative survival following tumor resection .
observed that TNF-[alpha] upregulated intercellular adhesion molecule 1 (ICAM1
) expression and fluid phase endocytosis (FPE) of horseradish peroxidase through kinase C (PKC) pathway, not through protein kinase A on brain microvascular endothelial cell (BMEC) culture .
Intercellular adhesion molecule 1 (ICAM1
) Lys56Met and Gly241Arg gene variants, plasma-soluble ICAM1
concentrations, and risk of incident cardiovascular events in 23,014 initially healthy white women.