ICAM3

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ICAM3

A gene on chromosome 19p13.3-p13.2 that encodes an intercellular adhesion molecule which, like all ICAMs, is a type-I transmembrane glycoprotein with multiple immunoglobulin-like C2-type domains, and which binds to leukocyte adhesion LFA-1 protein. ICAM3 is expressed by all leukocytes and is the most important ligand for LFA-1 in initiating the immune response, participating in adhesion and signalling.
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ICOS' clinical trials validated the role of ICAM-3 in T-cell activation and its importance in the course of psoriasis.
ICOS scientists discovered the adhesion molecule ICAM-3 that promotes an interaction between T cells and antigen presenting cells.