ICAM3

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ICAM3

A gene on chromosome 19p13.3-p13.2 that encodes an intercellular adhesion molecule which, like all ICAMs, is a type-I transmembrane glycoprotein with multiple immunoglobulin-like C2-type domains, and which binds to leukocyte adhesion LFA-1 protein. ICAM3 is expressed by all leukocytes and is the most important ligand for LFA-1 in initiating the immune response, participating in adhesion and signalling.
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Our results also show that either of leptin and OPN induced the surface expression of cluster of differentiation 18 (CD-18) and intercellular adhesion molecule 1 (ICAM-1), while downregulated those of ICAM-3 and L-selectin (Figures 2(e)-2(h)), especially when the two were given together.
On the other side, ICAM-3 is highly expressed on resting eosinophil surface [26].
ICAM-1 and ICAM-2 are mostly synthesized by vascular endothelial cells; however, ICAM-3 is synthesized by resting lymphocytes (Hernandez-Caselles et al., 1993).
ICAM-3, the third LFA-1 counterreceptor, is a co-stimulatory molecule for both resting and activated T lymphocytes.