ICAM2

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ICAM2

A gene on chromosome 17q23-q25 that encodes an intercellular adhesion molecule, which, like all ICAMs, is a type-I transmembrane glycoprotein with multiple immunoglobulin-like C2-type domains, and which binds to leukocyte adhesion LFA-1 protein. ICAM2 is involved in lymphocyte recirculation and mediates adhesive interactions critical for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation and other cellular interactions of the immune response and surveillance.
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Treatment of PA resulted in down-regulation of STAB-1, GRB-2, CD63 and ICAM-2 in HUVECs.
Abbreviations PA Panduratin A HUVECs human umbilical vein endothelial cells iTRAQ isobaric tags for relative and absolute quantification IPA Ingenuity Pathway Analysis mTOR mammalian target of rapamycin protein kinase VEGF vascular endothelial growth factor HIF1[alpha] hypoxia-inducible factor l[alpha] GRB-2 growth factor receptor-bound protein 2 STAB-1 stabilin-1 ICAM-2 Intercellular adhesion molecule-2 CTNND1 p120-catenin ARPC2 actin-related protein 2/3 complex subunit 2 STMN1 stathmin PI propidium iodide ANOVA one-way analysis of variance VE-cadherin vascular endothelial cadherin ARTICLE INFO
Nourshargh, "Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1," Blood, vol.