In conclusion, mechanical stretch increased miR-551b-5p expression, which promoted HUVECs proliferation and upregulated EGR-1 expression, thereby inducing endothelial dysfunction via upregulating of ICAM-1
At the site of inflammation, proinflammatory cytokines lead to increased expression of ICAM-1
on vascular endothelium and activation of leukocyte integrins, which results in the adhesion of leukocytes to endothelial cells and migration to the site of inflammation.
The aim of the present study is to search the association of ICAM-1
, VCAM-1, Cyclin D1 and Cathepsin D immunohistochemically with clinicopathological parameters in the patients diagnosed with invasive ductal breast carcinoma.
Apart from the risk factors ICAM-1
also had a positive correlation with fibrinogen, tissue-type plasminogen activator antigen, and total homocysteine which are hallmarks of chronic inflammation12.
Non-stimulated HAECs did not express E-selectin and VCAM-1; while ICAM-1
and PECAM-1 were expressed (Fig.
It is also more efficacious than its monomer in preventing TNF-[alpha]-induced upregulation of ICAM-1
and VCAM-1 on EC surface and their secretion in culture supernatants.
The amount of sICAM-1 is proportional to the number of cell surface molecules and the concentration of sICAM-1 was indirectly reflecting the expression of ICAM-1
on endothelial cells and antigen-presenting cell surface.
This lozenge is more palatable than many commercial brands while delivering an ideal potency of the proper form of zinc to block the ICAM-1
The mRNA expression level was expressed as the ratio of ICAM-1
to [beta]-actin band luminosity.
and VCAM-1 levels were measured by using precoated ELISA kit (Cusabio, China) that employed the sandwich enzyme immunoassay technique for quantitative measurement of human ICAM-1
and VCAM-1 concentrations.
This was also the case with the regulation of ICAM-1
concentrations were measured at the Molecular Epidemiology and Biomarker Research Laboratory in the University of Minnesota, using serum samples diluted 1:400-fold from exam year 15.