IA-2 autoantibody

IA-2 autoantibody

An autoantibody against islet cells, found in patients with type 1 diabetes mellitus and, frequently, in their close relatives.
References in periodicals archive ?
Laboratory results of the patient's workup for diabetes mellitus most consistent with A-[beta]+ ketosis-prone diabetes mellitus Normal Lab test Result range Interpretation C-peptide (ng/mL) 5.5 1.1-4.4 Pancreatic beta cell function intact GAD-65 autoantibody <5.0 0.0-5.0 Insignificant autoantibody (U/mL) levels to GAD-65 IA-2 autoantibody Negative Negative Insignificant autoantibody levels to islet cells GAD indicates glutamic acid decarboxylase.
Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes.
[6] Nonstandard abbreviations: ICA, islet cell antibody; GAD65, 65-kDa isoform of glutamic acid decarboxylase; IA-2, protein tyrosine phosphatase-like protein; IA-2A, IA-2 autoantibody; IA-tic, intracellular part of IA-2; RBA, radiobinding assay; GADA, GAD65 autoantibody; CST, glutathione S-transferase; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide gel electrophoresis; TBST, Tris-buffered saline-Tween; RU, relative unit(s); and DASP, Diabetes Autoantibody Standardization Program.