Hytrin


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Related to Hytrin: Proscar

terazosin hydrochloride

Apo-Terazosin, Dom-Terazosin, Hytrin, Novo-Terazosin, Nu- Terazosin, PHL-Terazosin, PMS-Terazosin, Ratio-Terazosin

Pharmacologic class: Anti-adrenergic (peripherally acting)

Therapeutic class: Antihypertensive

Pregnancy risk category C

Action

Blocks postsynaptic alpha1-adrenergic receptors, causing vasodilation and decreasing smooth muscle contractions in bladder neck and prostate

Availability

Capsules: 1 mg, 2 mg, 5 mg, 10 mg

Indications and dosages

Hypertension

Adults: Initially, 1 mg P.O., increased slowly as needed up to 5 mg/day. Usual range is 1 to 5 mg/day, not to exceed 20 mg/day.

Benign prostatic hyperplasia

Adults: 1 mg P.O. at bedtime. To achieve desired response, may increase gradually to 2 mg/day, then to 5 mg/day, and then to a maximum of 10 mg/day.

Contraindications

• Hypersensitivity to drug or other quinazoline derivatives

Precautions

Use cautiously in:

• prostate cancer, hepatic disease, dehydration, volume or sodium depletion

• pregnant or breastfeeding patients

• children (safety not established).

Administration

Don't stop therapy suddenly. Dosage must be tapered.

• Know that drug may be given as a single dose at bedtime or in two divided doses.

Adverse reactions

CNS: dizziness, headache, weakness, drowsiness, nervousness, paresthesia, vertigo, fatigue, syncope

CV: orthostatic hypotension (with first dose), rebound hypertension, chest pain, palpitations, peripheral edema, tachycardia, arrhythmias

EENT: blurred vision, conjunctivitis, amblyopia, nasal congestion, sinusitis

GI: nausea, vomiting, diarrhea, abdominal pain, dry mouth

GU: urinary frequency or incontinence, erectile dysfunction, priapism

Musculoskeletal: joint, back, and extremity pain; arthritis

Respiratory: dyspnea

Skin: pruritus

Other: fever, weight gain, flulike symptoms

Interactions

Drug-drug. Estrogens, nonsteroidal anti-inflammatory drugs (NSAIDs), sympathomimetics: decreased antihypertensive effects

Midodrine: antagonism of terazosin's action

Nitrates, other antihypertensives: additive hypotension

Drug-herbs. Ephedra (ma huang): antagonism of terazosin's action

Drug-behaviors. Alcohol use: additive hypotension

Patient monitoring

• Monitor blood pressure. Stay alert for orthostatic hypotension (first-dose effect) when therapy begins.

• Assess cardiovascular status. Report chest pain, peripheral edema, palpitations, and other significant effects.

Patient teaching

• Instruct patient to take at same time every day, with or without food.

Caution patient not to stop therapy abruptly. Dosage must be tapered.

Advise patient to immediately report swelling, breathing difficulty, palpitations, chest pain, and other cardiovascular reactions.

• Tell patient drug may cause erectile dysfunction and other sexual problems.

• Caution patient not to use NSAIDs or drink alcohol.

• Instruct patient to move slowly when sitting up or standing, to avoid dizziness from sudden blood pressure decrease.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, herbs, and behaviors mentioned above.

Hytrin

(hī′trĭn′)
A trademark for the drug terazosin hydrochloride.

Hytrin®

Terazosin, see there.

Hytrin

A brand name for TERAZOSIN.
References in periodicals archive ?
Nerve Blockers Generic Name Trade Name rauwolfia derivatives Reserpine guanethidine Ismelin guanadrel Hylorel alpha methyldopa Aldomlet clonidine Catapres guanabenz Wytensin prazosin Minipress terazosin Hytrin Beta Blockers propranolol Inderal metoprolol Lopressor nadolol Corgard atenolol Tenormin timolol Blocadren pindolol Visken acebutolol Sectral labetolol Normodyne or Trandate Blood Vessel Dilators hydralazine, Apresoline minoxidil Loniten(**) Hormone inhibitors captopril Capoten enalapril Vasotec lisinopril Prinivel or Zestril Calcium Channel Blockers nifedipine Procardia verapamil Isoptin or Calan diltiazem Cardizem nicardipine Cardene (*) Many combinations of these drugs are available--usually with a diuretic.
Abbott's patent was directed to crystalline forms of terazosin hydrochloride, which is the active ingredient in Hytrin. As was the case with Cardizem, there also existed a patent on the terazosin hydrochloride itself, but it had expired by the time the first ANDAs were filed.
began the FDA approval process for its generic Hytrin bioequivalent.
The results from the terazosin (Hytrin) and doxazosin (Cardura) studies were included with the tamsulosin studies.
relating to Abbott's branded drug Hytrin. (49) The Commission's complaint alleged that Abbott paid Geneva approximately $4.5 million per month to delay, the entry of its generic Hytrin product, potentially costing consumers hundreds of millions of dollars a year.
The company has received approval for a generic version of Hytrin (Abbott Laboratories).
clonidine (Catapres) terazosin (Hytrin) Diuretics: Cause water loss, which Thiazide Diuretics: reduces workload on the bendroflumethiazide (Naturetin) heart.
(Commonly used alpha blockers include Minipress, Hytrin, Cardura.)
Prescription drugs provide some relief for some men, but with the risk of diminished sex drive (Proscar) or dizziness (Hytrin).
Proscar, one of the most commonly used drugs in the United States for BPH, is associated with gastrointestinal distress and impotency Hytrin is used even less frequently for BPH because of side effects such as hypotension, edema, dizziness, nasal congestion, chest pain, and impotency, he noted.
The FDA has approved only one alpha blocker for BPH -- terazosin (Hytrin).
Examples of these antisympathetic drugs are prazosin (Minipress), phenoxybenzamine (Dibenzyline), and terazosin (Hytrin).