hypoxanthine phosphoribosyltransferase


Also found in: Acronyms.

hy·po·xan·thine phos·pho·ri·bo·syl·trans·fer·ase

an enzyme present in human tissue that catalyzes the conversion of hypoxanthine and guanine to their respective 5' nucleotides, with 5-phosphoribose 1-diphosphate as the ribose-phosphate donor; a partial deficiency of this enzyme can result in elevated purine biosynthesis leading to gout; another level of deficiency is associated with Lesch-Nyhan syndrome.
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6] Human genes: CDH16, cadherin 16, KSP-cadherin; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); HPRT1, hypoxanthine phosphoribosyltransferase 1; PPIA, peptidylprolyl isomerase A (cyclophilin A); KLK3, kallikrein-related peptidase 3; TBP, TATA box binding protein; RN18S1, RNA, 18S ribosomal 1; MIR155HG, MIR155 host gene (nonprotein coding).
4] Human genes: RPLPO, ribosomal protein, large, P0; PPIA, peptidylprolyl isomerase A (cyclophilin A); TNFRSF1A, tumor necrosis factor receptor superfamily, member 1A; CCL11, CCL17, CCL19, CCL22, CCL3, CCL4, chemokine (C-C motif) ligand 11, 17, 19, 22, 3, and 4; CL5 chemokine (C-C motif) ligand 5; CCR1, CCR7, CCR8, chemokine (C-C motif) receptor 1, 7, and 8; CD86, CD86 molecule; CXCL12, chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXCL2, chemokine (C-X-C motif) ligand 2; CXCR4, chemokine (C-X-C motif) receptor 4; L128, interleukin 12B (natural killer cell-stimulating factor 2, cytotoxic lymphocyte maturation factor 2, p40); IL15, IL4, IL8, interleukin 15, 4, and 8; HPRT1, hypoxanthine phosphoribosyltransferase 1; PGK1, phosphoglycerate kinase 1.
Concentrations of the target genes, expressed relative to our housekeeping set [low-abundance housekeeping gene hydroxymethylbilane synthase (HMBS, formerly porphobilinogen deaminase, PBGD), medium-abundance hypoxanthine phosphoribosyltransferase (HPRT), and highabundance [[beta].
2]-microglobulin (B2M), glucose-6-phosphate dehydrogenase (G6PD), hypoxanthine phosphoribosyltransferase 1 (HPRT1), and hydroxymethylbilane synthase (HMBS; formerly PBGD, porphobilinogen deaminase), as potential references for relative quantification.
5] Human genes: TERT, telomerase reverse transcriptase (Homo sapiens); HPRT, hypoxanthine phosphoribosyltransferase.