11] EEG studies have shown its ability to regulate faulty sleep patterns,  and another study has shown its ability to stimulate the hypothalamic-pituitary axis
to increase insulin-like growth factor-1 in older female patients.
High FSH levels indicate lack of gonadal function or responsiveness despite a mature hypothalamic-pituitary axis
It does, however, require careful evaluation to determine whether the emerging pubertal features reflect a central process driven by hypothalamic and pituitary factors or whether the problem is peripheral, reflecting abnormally elevated sex steroid hormones but no hypothalamic-pituitary axis aberrations.
If the hypothalamic-pituitary axis is "revved"--pubertal--there will be a massive surge in gonadotropin levels following infusion.
Altered reactivity of the hypothalamic-pituitary axis
in the primary fibromyalgia syndrome.
In contrast, changes in sensitivity of the hypothalamic-pituitary axis
to the feedback actions of gonadal steroids mediate steroid-dependent control of LH release.
Key words: gonadotropin-releasing hormone, hypothalamic-pituitary axis, lead acetate.
The data presented here show that low doses of lead for long periods of time alter the rat hypothalamic-pituitary axis in a manner similar to that previously reported at higher doses for shorter periods of time.
Castrated, lead-treated male rats are able to respond to castration with an increase in LH, indicating an adaptation of the hypothalamic-pituitary axis to the toxic effects of lead (23).