hypomelanosis


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Related to hypomelanosis: Idiopathic guttate hypomelanosis

leu·ko·der·ma

(lū'kō-der'mă),
An absence of pigment, partial or total, in the skin.
[leuko- + G. derma, skin]

hypomelanosis

(hi?po-mel-an-o'sis)
One of several disorders of melanin pigmentation in which melanin in the epidermis is decreased or absent. It may be caused by albinism, chronic protein deficiency, burns, trauma, or vitiligo.
See: hypermelanosis
References in periodicals archive ?
Given our patient's dermatologic findings, she was clinically diagnosed with Hypomelanosis of Ito, though it was never confirmed through genetic testing.
Our patient's left leg being notably bigger than her right leg represents a limb discrepancy previously identified in other patients with Hypomelanosis of Ito [5].
From 40% to 60% of patients with hypomelanosis of Ito will have structural brain abnormalities or mental retardation with or without seizures.
If hypomelanosis of Ito is suspected because of skin lesions but the child is meeting developmental milestones, there's no need to do a genetic work-up for this disorder, she said.
OF CASES WHORLED NEVOID HYPERMELANOSIS 1 PAEDERUS DERMATITIS 2 LINEAR LICHEN PLANUS 5 LICHEN STRIATUS 17 LICHEN NITIDUS 2 INFLAMMATORY LINEAR VERRUCOUS EPIDERMAL NEVUS 2 HYPOMELANOSIS OF ITO 1 Note: Table made from bar graph.
Thus, despite current lack of a definitive genetic explanation, it has been suggested that HI is not a single condition, but a rather nonspecific manifestation (ie, a phenotype) of different chromosomal mosaicism and that the term hypomelanosis of Ito should now be dropped.[2,3,9,10] Proposed Changes to terminology, so far, include the terms pigmentary dysplasia, mosaic dyspigmentation, pigmentary mosaicism of the Ito type, or hypopigmentation along the lines of Blaschko to reflect the disease pathogenesis or recall the cutaneous patterns.[9,10]
Primary meningeal rhabdomyosarcoma in a child with hypomelanosis of Ito.
Progressive macular hypomelanosis (PMH) is an uncommon skin disorder characterized by ill-defined nummular, non-scaly hypopigmented confluent macules on the trunk, often in and around the midline, and rarely extending to the proximal extremities and neck/head region.
[5] The common pigmentary disorders encountered were idiopathic guttate hypomelanosis (36.7%), vitiligo (2.9%), lentigenes (6.9%) and melasma (8%).
Idiopathic guttate hypomelanosis was present in 99 (33%) cases in this study.
Idiopathic guttate hypomelanosis. Arch Dermatol 1966; 94: 279-81.
My 12-year-old daughter was diagnosed with hypomelanosis of Ito (a rare disorder characterized by an unusual lack of skin color affecting many areas of the body and associated with other symptoms, such as mental retardation, seizuresvisual and ocular defects, overgrowth of brain tissue, and/or a small head) at the age of 2 years.